Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Structural Biology of Eastern Equine Encephalitis Virus, an Emerging Viral Threat

Version 1 : Received: 21 July 2021 / Approved: 22 July 2021 / Online: 22 July 2021 (07:52:20 CEST)

How to cite: Hasan, S.S.; Dey, D.; Singh, S.; Martin, M. The Structural Biology of Eastern Equine Encephalitis Virus, an Emerging Viral Threat. Preprints 2021, 2021070508 (doi: 10.20944/preprints202107.0508.v1). Hasan, S.S.; Dey, D.; Singh, S.; Martin, M. The Structural Biology of Eastern Equine Encephalitis Virus, an Emerging Viral Threat. Preprints 2021, 2021070508 (doi: 10.20944/preprints202107.0508.v1).

Abstract

Alphaviruses are arboviruses that cause arthritis and encephalitis in humans. Eastern Equine Encephalitis Virus (EEEV) is a mosquito transmitted alphavirus that is implicated in severe encephalitis in humans with high mortality. However, limited insights are available into its fundamental biology of EEEV and residue-level details of its interactions with host proteins. In recent years, outbreaks of EEEV have been reported mainly in the United States, raising concerns about public safety. This review article summarizes recent advances in the structural biology of EEEV based mainly on recent single particle cryogenic electron microscopy (cryoEM) structures. Together with functional analyses of EEEV and related alphaviruses, these structural investigations provide clues to how EEEV interacts with host proteins, which may open avenues for the development of therapeutics.

Subject Areas

Alphavirus; Antibody; Assembly; Eastern Equine Encephalitis Virus; Structure

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