Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-Like Lesions: A Multicenter Retrospective Study

Version 1 : Received: 1 July 2021 / Approved: 6 July 2021 / Online: 6 July 2021 (11:25:42 CEST)

A peer-reviewed article of this Preprint also exists.

Aiba, H.; Ikuta, K.; Asanuma, K.; Kawanami, K.; Tsukushi, S.; Matsumine, A.; Ishimura, D.; Nagano, A.; Shido, Y.; Kozawa, E.; Yamada, K.; Wasa, J.; Kimura, H.; Sakai, T.; Murakami, H.; Sakai, T.; Nakamura, T.; Nishida, Y. Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study. Cancers 2021, 13, 3901. Aiba, H.; Ikuta, K.; Asanuma, K.; Kawanami, K.; Tsukushi, S.; Matsumine, A.; Ishimura, D.; Nagano, A.; Shido, Y.; Kozawa, E.; Yamada, K.; Wasa, J.; Kimura, H.; Sakai, T.; Murakami, H.; Sakai, T.; Nakamura, T.; Nishida, Y. Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study. Cancers 2021, 13, 3901.

Journal reference: Cancers 2021, 13, 3901
DOI: 10.3390/cancers13153901

Abstract

Several types of soft tissue sarcomas have peripheral infiltrative growth characteristics called tail-like lesions. The efficacy of neoadjuvant therapy for tumors with tail-like lesions has not been elucidated. From 2012 to 2019, we analyzed 36 patients with soft tissue sarcoma with tail-like lesions treated with neoadjuvant therapy, including chemotherapy, radiotherapy, or both. The ef-fect of neoadjuvant therapy on the tail sign was investigated by analyzing the change in tail-like lesions during neoadjuvant therapy and histological responses. The median length of the tail-like lesion reduced from 29.5 mm at initiation to 19.5 mm after neoadjuvant therapy. The extent of shrinkage in tail-like lesion was related to the histopathological responses in the main part. Com-plete disappearance of the tail-like lesion was observed in 12 patients; however, it was not related to achieving a microscopically negative margin. The oncologic outcomes did not significantly differ between cases with complete disappearance of tail-like lesions or not. This study indicated the shrinkage of tail-like lesions did not have significant effect on complete resection or improve-ment of clinical outcomes. A more comprehensive evaluation is needed to elaborate on the surgi-cal strategy.

Keywords

Neoadjuvant therapy; Soft tissue tumor; Sarcoma; Tail sign; Radiotherapy; Chemotherapy; Hyperthermia; Surgery

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