Preprint Article Version 3 Preserved in Portico This version is not peer-reviewed

Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation

Version 1 : Received: 24 May 2021 / Approved: 25 May 2021 / Online: 25 May 2021 (11:49:42 CEST)
Version 2 : Received: 9 June 2021 / Approved: 9 June 2021 / Online: 9 June 2021 (13:13:03 CEST)
Version 3 : Received: 16 June 2021 / Approved: 17 June 2021 / Online: 17 June 2021 (10:02:24 CEST)
(This article belongs to the Research Topic Ecofriendly Materials)

A peer-reviewed article of this Preprint also exists.

Journal reference: polymers 2021, 13, 1999
DOI: 10.3390/polym13121999


A technique for fabrication of bacterial cellulose-based films with CeO2 nanofiller has been developed. The structural and morphological characteristics of the materials have been studied, their thermal and mechanical properties in dry and swollen states having been determined. The preparation methodology makes it possible to obtain composites with a uniform distribution of nanoparticles. The catalytic effect of ceria regarding the thermal oxidative destruction of cellulose has been confirmed by TGA and DTA methods. An increase in CeO2 content led to an increase in the elastic modulus (a 1.27-fold increase caused by the introduction of 5 wt.% of the nanofiller into the polymer) and strength of the films. This effect is explained by the formation of additional links between polymer macro-chains via the nanoparticles’ surface. The materials fabricated were characterised by a limited ability to swell in water. Swelling caused a 20- to 30-fold reduction in the stiffness of the material, the mechanical properties of the films in a swollen state remaining germane to their practical use. The application of the composite films in cell engineering as substrates for the stem cells’ proliferation has been studied. The increase in CeO2 content in the films enhanced the proliferative activity of embryonic mouse stem cells. The cells cultured on the scaffold containing 5 wt.% of ceria demonstrated increased cell survival and migration activity. An analysis of gene expression confirmed improved cultivation conditions on CeO2-containing scaffolds.


nanocomposites; bacterial cellulose; ceria nanoparticles; thermal properties; swelling; mechanical behavior; biomedical applications; stem cells proliferation; gene expression



Comments (1)

Comment 1
Received: 17 June 2021
Commenter: Ios Go
Commenter's Conflict of Interests: Author
Comment: The authors have modified the peer-reviewed text following the suggestion of Academic Editor.
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