Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Acceptability, Appropriateness, and Feasibility of Automated Screening Approaches and Family Communication Methods for Identification of Familial Hypercholesterolemia: Stakeholder Engagement Results from the IMPACT-FH study

Laney K Jones
* ORCID logo ,
Nicole Walters
ORCID logo ,
Andrew Brangan
,
Catherine D Ahmed
,
Michael Gatusky
,
Gemme Campbell-Salome
,
Ilene G Ladd
,
Amanda Sheldon
,
Samuel S Gidding
,
Mary P McGowan
ORCID logo ,
Alanna K Rahm
,
Amy C Sturm
Version 1 : Received: 13 May 2021 / Approved: 14 May 2021 / Online: 14 May 2021 (14:49:21 CEST)

A peer-reviewed article of this Preprint also exists.

Jones, L.K.; Walters, N.; Brangan, A.; Ahmed, C.D.; Gatusky, M.; Campbell-Salome, G.; Ladd, I.G.; Sheldon, A.; Gidding, S.S.; McGowan, M.P.; Rahm, A.K.; Sturm, A.C. Acceptability, Appropriateness, and Feasibility of Automated Screening Approaches and Family Communication Methods for Identification of Familial Hypercholesterolemia: Stakeholder Engagement Results from the IMPACT-FH Study. J. Pers. Med. 2021, 11, 587. Jones, L.K.; Walters, N.; Brangan, A.; Ahmed, C.D.; Gatusky, M.; Campbell-Salome, G.; Ladd, I.G.; Sheldon, A.; Gidding, S.S.; McGowan, M.P.; Rahm, A.K.; Sturm, A.C. Acceptability, Appropriateness, and Feasibility of Automated Screening Approaches and Family Communication Methods for Identification of Familial Hypercholesterolemia: Stakeholder Engagement Results from the IMPACT-FH Study. J. Pers. Med. 2021, 11, 587.

Abstract

Guided by the Conceptual Model of Implementation Research, we explored the acceptability, appropriateness, and feasibility of: 1) automated screening approaches utilizing existing health data to identify those who require subsequent diagnostic evaluation for familial hypercholesterolemia (FH) and 2) family communication methods including chatbots and direct contact to communicate information about inherited risk for FH. Focus groups were conducted with 22 individuals with FH (2 groups) and 20 clinicians (3 groups). These were recorded, transcribed, and analyzed using deductive (coded to implementation outcomes) and inductive (themes based on focus group discussions) methods. All stakeholders described these initiatives as: 1) acceptable and appropriate to identify individuals with FH and communicate risk with at-risk relatives; and 2) feasible to implement in current practice. Stakeholders cited current initiatives, outside of FH (e.g., pneumonia protocols, colon cancer and breast cancer screenings), that gave them confidence for successful implementation. Stakeholders described perceived obstacles, such as nonfamiliarity with FH, that could hinder implementation and potential solutions to improve systematic uptake of these initiatives. Automated health data screening, chatbots, and direct contact approaches may be useful for patients and clinicians to improve FH diagnosis and cascade screening.

Keywords

Familial hypercholesterolemia; identification; implementation outcomes; cascade screening; cascade testing; chatbots; direct contact

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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