Convection Enhanced Delivery in the Setting of High-Grade Gliomas

Chibueze D. Nwagwu; Amanda V. Immidisetti; Michael Jiang; Oluwasegun Adeagbo; David Cory Adamson; Anne-Marie Carbonell

doi:10.20944/preprints202103.0342.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 11 March 2021 / Approved: 12 March 2021 / Online: 12 March 2021 (15:01:51 CET)

Development of effective treatments for high-grade glioma (HGG) is hampered by 1) the blood-brain barrier (BBB), 2) an infiltrative growth pattern, 3) rapid development of therapeutic resistance, and, in many cases, 4) dose-limiting toxicity due to systemic exposure. Convec-tion-enhanced delivery (CED) has the potential to significantly limit systemic toxicity and in-crease therapeutic index by directly delivering homogenous drug concentrations to the site of disease. In this review, we present clinical experiences and preclinical developments of CED in the setting of high-grade gliomas.

glioblastoma; high-grade glioma; refractory glioma; direct delivery; convection enhanced delivery; neuro-oncology; refractory glioblastoma; clinical trials

Medicine and Pharmacology, Oncology and Oncogenics

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Convection Enhanced Delivery in the Setting of High-Grade Gliomas

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