Working Paper Article Version 1 This version is not peer-reviewed

Enhancer RNA ADCY10P1 in Pan-Cancer

Version 1 : Received: 10 January 2021 / Approved: 12 January 2021 / Online: 12 January 2021 (10:49:38 CET)

How to cite: Luo, Q.; Vögeli, T. Enhancer RNA ADCY10P1 in Pan-Cancer. Preprints 2021, 2021010215 Luo, Q.; Vögeli, T. Enhancer RNA ADCY10P1 in Pan-Cancer. Preprints 2021, 2021010215

Abstract

Background. Enhancer RNA(eRNA) ADCY10P1 is derived from enhancer regions and may have enhancer function. Methods: Publicly available data was downloaded from The Cancer Genome Atlas (TCGA) and expression of ADCY10P1 was compared in normal tissue and pan-cancer tissue. Over survival time was analyzed. Correlations between ADCY10P1 expression and immune infiltration was analyzed. ADCY10P1-related genes were found to perform Gene Ontology (GO) analysis and Genes and Genomes (KEGG) analysis.Results. ADCY10P1 expression was higher in most cancer groups, including KIRP, BLCA, LUAD, LUSC, STAD, and THCA. ADCY10P1 showed a protective effect on BLCA, LAML, LGG, READ, and THYM. The results of Gene Ontology (GO) analysis and Genes and Genomes (KEGG) analysis in BLCA and LGG.Conclusion. ADCY10P1 can affect pan-cancer progress and prognosis. ADCY10P1 was an independent prognostic factor in BLCA and LGG. High expression of ADCY10P1 is beneficial to BLCA, LAML, LGG, READ, and THYM. High expression may suppress immune infiltration. ADCY10P1 may have a direct or indirect trans function. ADCY10P1 may have a dual role in the tumor, which is oncogenes and tumor suppressor genes in BLCA and READ.

Subject Areas

Enhancer RNA; ADCY10P1; Pan-cancer; Immune

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