Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Stick around: Cell-Cell Adhesion Molecules during Neocortical Development

Version 1 : Received: 9 December 2020 / Approved: 10 December 2020 / Online: 10 December 2020 (10:23:42 CET)

A peer-reviewed article of this Preprint also exists.

de Agustín-Durán, D.; Mateos-White, I.; Fabra-Beser, J.; Gil-Sanz, C. Stick around: Cell–Cell Adhesion Molecules during Neocortical Development. Cells 2021, 10, 118. de Agustín-Durán, D.; Mateos-White, I.; Fabra-Beser, J.; Gil-Sanz, C. Stick around: Cell–Cell Adhesion Molecules during Neocortical Development. Cells 2021, 10, 118.

Journal reference: Cells 2021, 10, 118
DOI: 10.3390/cells10010118

Abstract

The neocortex is an exquisitely organized structure achieved through complex cellular processes from the generation of neural cells to their integration into cortical circuits after complex migration processes. During this long journey, neural cells need to stablish and release adhesive interactions through cell surface receptors known as cell adhesion molecules (CAMs). Several types of CAMs have been described regulating different aspects of neurodevelopment. Whereas some of them mediate interactions with the extracellular matrix, others allow contacts with additional cells. In this review, we will focus on the role of two important families of cell-cell adhesion molecules (C-CAMs), classical cadherins and nectins, as well as in their effectors, in the control of fundamental processes related with corticogenesis, with especial attention in the cooperative actions among the two families of C-CAMs.

Subject Areas

CAMs; Classical Cadherins; Nectins; Neocortical Development; Radial Glia Cells; Neurons; Neuronal Migration; Axon Targeting; Synaptogenesis; Autism/Neurodevelopmental disorders

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