Therapeutic potential of mesenchymal stem/stromal cells-derived exosomes in acute respiratory distress syndrome and COVID-19

Yueyuan Zhou; Yusuke Yamamoto; Zhongdang Xiao; Takahiro Ochiya

doi:10.20944/preprints202012.0097.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 3 December 2020 / Approved: 4 December 2020 / Online: 4 December 2020 (10:10:11 CET)

Coronavirus disease 2019 (COVID-19) caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has reached a global epidemic across the world after first reported in Wuhan, China’s Hubei province in December 2019. The pandemic is also associated with acute respiratory distress syndrome (ARDS) characterized by excess inflammation, progressive arterial hypoxemia and dyspnea. Mesenchymal stem/ stromal cells (MSCs) have been investigated as treatment for ARDS due to immunomodulatory property. Exosomes derived from MSCs play an important role in paracrine signaling of MSCs, thereby contributed to immunomodulation of the immune microenvironment. Exosomes are emerged as potential alternative to MSC cell therapy with superiority of safety. In this review, we will introduce MSC-derived exosomes and briefly discuss current progress on MSCs and exosomes in ARDS, which may have clinical implications in pathogenesis and treatment of COVID-19.

acute respiratory distress syndrome; mesenchymal stem/stromal cells,; exosome; COVID-19; Clinical trials

LIFE SCIENCES, Molecular Biology

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Therapeutic potential of mesenchymal stem/stromal cells-derived exosomes in acute respiratory distress syndrome and COVID-19

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