Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease

Ye Rin Choi
ORCID logo ,
Hyeong Seop Kim
,
Sang Jun Yoon
ORCID logo ,
Na Young Lee
ORCID logo ,
Haripriya Gupta
ORCID logo ,
Ganesan Raja
ORCID logo ,
Yoseph Asmelash Gebru
,
Gi Soo Youn
,
Dong Joon Kim
ORCID logo ,
Young Lim Ham
* ,
Ki Tae Suk
* ORCID logo
Version 1 : Received: 2 December 2020 / Approved: 3 December 2020 / Online: 3 December 2020 (14:22:03 CET)

A peer-reviewed article of this Preprint also exists.

Choi, Y.R.; Kim, H.S.; Yoon, S.J.; Lee, N.Y.; Gupta, H.; Raja, G.; Gebru, Y.A.; Youn, G.S.; Kim, D.J.; Ham, Y.L.; Suk, K.T. Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease. Nutrients 2021, 13, 185. Choi, Y.R.; Kim, H.S.; Yoon, S.J.; Lee, N.Y.; Gupta, H.; Raja, G.; Gebru, Y.A.; Youn, G.S.; Kim, D.J.; Ham, Y.L.; Suk, K.T. Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease. Nutrients 2021, 13, 185.

Abstract

Malnutrition and cognitive dysfunction are typical features of alcoholic liver disease (ALD) and are correlated with the development of complications. The aim of this study is to explore the effect of nutritional state and diet on cognitive function in ALD. A total of 43 patients with compensated alcoholic cirrhosis were enrolled, and neuropsychological test was assessed according to body mass index (BMI, <22 and ≥22). In the ALD animal study, mice were divided into 5 groups (n=9/group; normal liquid, 5% EtOH+regular liquid, 5% EtOH+high-carbohydrate liquid, 5% EtOH+high-fat liquid, and 5% EtOH+high-protein liquid diet) and fed the same calories for 8-week. To assess cognitive function, we performed T-maze studies weekly before/after alcohol binging. In cognitive function (BMI <22 /≥22), language score of Korea mini-mental state (7.4±1.4/7.9±0.4), Rey-complex figure (72.0±25.9/58.4±33.6), Boston naming (11.7±2.7/13.0±1.8), forward digit span (6.7±1.8/7.5±1.6), Korean Color Word Stroop (24.2±26.5/43.6±32.4), and interference score (33.9±31.9/52.3±33.9) revealed significant differences. In the T-maze test, alcohol significantly delayed the time to reach food, and binge drinking provided a temporary recovery in cognition. The alcohol-induced delay was significantly reduced in the high-carbohydrate and high-fat diet groups. Synaptic function exhibited no changes in all groups. Cognitive dysfunction is affected by nutritional status and diet in ALD.

Keywords

alcoholic liver disease; cognitive function; calorie intake; nutrition; BMI

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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