Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

MicroRNAs as the Promising Markers of Comorbidities in Childhood Obesity – A Systematic Review

Version 1 : Received: 14 November 2020 / Approved: 16 November 2020 / Online: 16 November 2020 (15:44:40 CET)

How to cite: Hutny, M.; Hofman, J.; Zachurzok, A.; Matusik, P. MicroRNAs as the Promising Markers of Comorbidities in Childhood Obesity – A Systematic Review. Preprints 2020, 2020110433 (doi: 10.20944/preprints202011.0433.v1). Hutny, M.; Hofman, J.; Zachurzok, A.; Matusik, P. MicroRNAs as the Promising Markers of Comorbidities in Childhood Obesity – A Systematic Review. Preprints 2020, 2020110433 (doi: 10.20944/preprints202011.0433.v1).

Abstract

Rising child obesity rate creates a need for tools quantifying metabolic changes in obese children and adolescents for purposes of comorbidities early detection or prevention. A candidate for such role seem to be miRNAs – in vivo serving as the suppressing factors of the gene expression. The aim of this study was to review the recent discoveries in this field and to conclude directions of research or application of studied molecules. Repeated browsing of databases, followed by screening for eligibility of results, led to final approval of 9 articles. Filtered studies examined the differences in miRNA (miR) expression levels of obese subjects and children suffering from obesity comorbidities. Studies concerning the endothelial dysfunction (ED) identified miR-630 as a possible treatment option. Search for the alternative markers in diagnosis of non-alcoholic fatty liver disease (NAFLD) suggested value of miR-199a-5p and miR-122. MiR-486, miR-146b and miR-15b may serve as a panel of markers grading the development of type 2 diabetes mellitus (T2DM) in children, although further research raised doubts in that matter. Another panel of miRNA molecules was indicated as useful in early detection of alterations leading to metabolic syndrome (MetS). No valid link between studied miRNAs and atherosclerosis (AS) was found. MiRNAs seem to be promising prognostic markers for the diagnosis of NAFLD, T2DM and MetS in children. Further studies are required to support these findings.

Subject Areas

miRNAs; Obesity; Children; Non-alcoholic fatty liver disease; Type 2 diabetes mellitus; Endothelial dysfunction

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.