Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases

Version 1 : Received: 7 November 2020 / Approved: 9 November 2020 / Online: 9 November 2020 (10:39:02 CET)
Version 2 : Received: 23 December 2020 / Approved: 24 December 2020 / Online: 24 December 2020 (09:55:13 CET)

A peer-reviewed article of this Preprint also exists.

Battistini, C.; Ballan, R.; Herkenhoff, M.E.; Saad, S.M.I.; Sun, J. Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases. Int. J. Mol. Sci. 2021, 22, 362. Battistini, C.; Ballan, R.; Herkenhoff, M.E.; Saad, S.M.I.; Sun, J. Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases. Int. J. Mol. Sci. 2021, 22, 362.

Journal reference: Int. J. Mol. Sci. 2020, 22, 362
DOI: 10.3390/ijms22010362

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal0 tract (GIT), including Crohn’s disease (CD) and ulcerative colitis (UC), which differ in the location and lesion extensions. Both diseases are associated with microbiota dysbiosis, with a reduced population of butyrate-producing species, abnormal inflammatory response, and micronutrient deficiency (e. g. vitamin D hypovitaminosis). Vitamin D (VitD) is involved in immune cell differentiation, gut microbiota modulation, gene transcription, and barrier integrity. Vitamin D receptor (VDR) regulates the biological actions of the active VitD (1α, 25-dihydroxyvitamin D3), and is involved in the genetic, environmental, immune, and microbial aspects of IBD. VitD deficiency is correlated with disease activity and its administration targeting a concentration of 30 ng/mL may have the potential to reduce disease activity. Moreover, VDR regulates functions of T cells and Paneth cells and modulates release of antimicrobial peptides in gut microbiota-host interactions. Meanwhile, beneficial microbial metabolites, e.g. butyrate, upregulate the VDR signaling. In this review, we summarize the clinical progress and mechanism studies on VitD /VDR related to gut microbiota modulation in IBD. We also discuss epigenetics in IBD and the probiotic regulation of VDR. Furthermore, we discuss the existing challenges and future directions. There is a lack of well-designed clinical trials exploring the appropriate dose and the influence of gender, age, ethnicity, genetics, microbiome, and metabolic disorders in IBD subtypes. To move forward, we need well-designed therapeutic studies to examine whether enhanced vitamin D will restore functions of VDR and microbiome in inhibiting chronic inflammation.

Subject Areas

Vitamin D; VDR; inflammation; microbiome; metabolites; nuclear receptor; probiotics; tight junctions

Comments (1)

Comment 1
Received: 24 December 2020
Commenter: Jun Sun
Commenter's Conflict of Interests: Author
Comment: We added two new figures and more Discussion. We also updated citations.
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