Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

Why are Some Listeria monocytogenes Genotypes More Likely to Cause Invasive (Brain, Placental) Infection?

Version 1 : Received: 5 November 2020 / Approved: 8 November 2020 / Online: 8 November 2020 (14:49:05 CET)

How to cite: Vazquez-Boland, J.; Wagner, M.; Scortti, M. Why are Some Listeria monocytogenes Genotypes More Likely to Cause Invasive (Brain, Placental) Infection?. Preprints 2020, 2020110257 (doi: 10.20944/preprints202011.0257.v1). Vazquez-Boland, J.; Wagner, M.; Scortti, M. Why are Some Listeria monocytogenes Genotypes More Likely to Cause Invasive (Brain, Placental) Infection?. Preprints 2020, 2020110257 (doi: 10.20944/preprints202011.0257.v1).

Abstract

Although all isolates of the foodborne pathogen Listeria monocytogenes are considered to be pathogenic, epidemiological evidence indicates that certain serovar 4b lineages are more likely to cause severe invasive (neuromeningeal, maternal-fetal) listeriosis. Recently described as L. monocytogenes “hypervirulent” clones, no distinctive bacterial trait has been identified so far that could account for the differential pathogenicity of these strains. Here we discuss some preliminary observations in experimentally infected mice suggesting that serovar 4b hypervirulent strains may have a hitherto unrecognized capacity for prolonged in vivo survival. We propose the hypothesis that protracted survivability in primary infection foci in liver and spleen –first target organs after intestinal translocation– may cause L. monocytogenes serovar 4b hypervirulent clones to have a higher probability of secondary dissemination to brain and placenta.

Subject Areas

Listeria monocytogenes; virulence heterogeneity; hypervirulent clones; prolonged in vivo survival; invasive listeriosis

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