Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Dietary Polyphenols in Metabolic Diseases and Neurodegeneration: Molecular Targets on Autophagy and Biological Effects

Version 1 : Received: 30 October 2020 / Approved: 2 November 2020 / Online: 2 November 2020 (17:30:15 CET)

A peer-reviewed article of this Preprint also exists.

García-Aguilar, A.; Palomino, O.; Benito, M.; Guillén, C. Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects. Antioxidants 2021, 10, 142. García-Aguilar, A.; Palomino, O.; Benito, M.; Guillén, C. Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects. Antioxidants 2021, 10, 142.

Journal reference: Antioxidants 2021, 10, 142
DOI: 10.3390/antiox10020142

Abstract

Polyphenols represent a group of secondary metabolites of plants which have been analyzed as potent regulators of multiple biological processes, including cell proliferation, apoptosis and autophagy, among others. These natural compounds exhibit beneficial effects and protection against inflammation, oxidative stress and related injuries including metabolic diseases, such as cardiovascular damage, obesity and diabetes and neurodegeneration. In the present review, we report the main biological effects in relationship to autophagy regulation in response to different dietary polyphenols and its impact on metabolic and neurodegenerative diseases

Keywords

polyphenols; autophagy; mechanisms; oxidative stress; inflammation; disease models

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