Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

The Aerogen® Solo is an Alternative to the Small Particle Aerosol Generator (SPAG-2) for Administration of Inhaled Ribavirin

Version 1 : Received: 27 October 2020 / Approved: 29 October 2020 / Online: 29 October 2020 (15:38:09 CET)

How to cite: Dallas, R.H.; Rains, J.K.; Wilder, K.; Humphrey, W.; Cross, S.J.; Ghafoor, S.; Brazelton de Cardenas, J.N.; Hayden, R.T.; Hijano, D.R. The Aerogen® Solo is an Alternative to the Small Particle Aerosol Generator (SPAG-2) for Administration of Inhaled Ribavirin. Preprints 2020, 2020100621 (doi: 10.20944/preprints202010.0621.v1). Dallas, R.H.; Rains, J.K.; Wilder, K.; Humphrey, W.; Cross, S.J.; Ghafoor, S.; Brazelton de Cardenas, J.N.; Hayden, R.T.; Hijano, D.R. The Aerogen® Solo is an Alternative to the Small Particle Aerosol Generator (SPAG-2) for Administration of Inhaled Ribavirin. Preprints 2020, 2020100621 (doi: 10.20944/preprints202010.0621.v1).

Abstract

Respiratory syncytial virus (RSV) is associated with adverse outcomes among immunocompromised patients. Inhaled ribavirin has been shown to improve mortality rates. The Small-Particle Aerosol Generator delivery system (SPAG-2) is the only FDA-cleared device to deliver inhaled ribavirin. However, it is difficult to set up and maintain. We developed a method for delivery of this medication using the vibrating mesh nebulizer (Aerogen®). We did not observe any adverse events with this method.

Subject Areas

RSV; ribavirin; Aerogen® solo; SPAG-2; children; infection

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