Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?

Version 1 : Received: 27 September 2020 / Approved: 28 September 2020 / Online: 28 September 2020 (11:03:25 CEST)

A peer-reviewed article of this Preprint also exists.

Kourakis, S.; Timpani, C.A.; de Haan, J.B.; Gueven, N.; Fischer, D.; Rybalka, E. Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility? Pharmaceuticals 2020, 13, 306. Kourakis, S.; Timpani, C.A.; de Haan, J.B.; Gueven, N.; Fischer, D.; Rybalka, E. Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility? Pharmaceuticals 2020, 13, 306.

Journal reference: Pharmaceuticals 2020, 13, 306
DOI: 10.3390/ph13100306

Abstract

Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is approved and registered for the treatment of psoriasis and Relapsing-Remitting Multiple Sclerosis (RRMS). Psoriasis and RRMS share an immune-mediated aetiology, driven by severe inflammation and oxidative stress. DMF, as well as monomethyl fumarate and diroximel fumarate, are commonly prescribed first-line agents with favourable safety and efficacy profiles. The potential benefits of FAEs against other diseases that appear pathogenically different but share the pathologies of oxidative stress and inflammation are currently investigated.

Subject Areas

Clinical application; dimethyl fumarate; disease; fumaric acid esters; oxidative stress; inflammation; Nrf2; disease

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