Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

RNA Polymerase and Transcription Mechanism: Forefront of Physicochemical Study as Chemical Reactions

Version 1 : Received: 20 August 2020 / Approved: 24 August 2020 / Online: 24 August 2020 (10:09:12 CEST)

A peer-reviewed article of this Preprint also exists.

Shimamoto, N.; Imashimizu, M. RNA Polymerase and Transcription Mechanisms: The Forefront of Physicochemical Studies of Chemical Reactions. Biomolecules 2021, 11, 32. Shimamoto, N.; Imashimizu, M. RNA Polymerase and Transcription Mechanisms: The Forefront of Physicochemical Studies of Chemical Reactions. Biomolecules 2021, 11, 32.

Journal reference: Biomolecules 2020, 11, 32
DOI: 10.3390/biom11010032

Abstract

Transcriptional regulations have been widely studied as one of the main bridges between biology and other basic sciences as well as medicine. The traffic across it has been mostly unidirectional: chemistry and physics provided a lot of tools for biology, although the supply is now saturating. The traffic in opposite direction, the supply of subjects to develop chemistry and physics, has been only a little. However, if there are any, the supply will be at least from transcription, because the notion of chemical reaction is the strongest. This topic is aimed to increase the opposite traffic by introducing the forefront of physicochemical studies of transcription.

Subject Areas

transcriptional regulation; reaction theory; prediction of promoters; one-dimensional diffusion; rate equation; detailed balance; antenna effect; physicochemical techniques

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