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Role of the Cation-chloride-cotransporters in Cardiovascular Disease
Version 1
: Received: 19 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (13:00:59 CEST)
A peer-reviewed article of this Preprint also exists.
Meor Azlan, N.F.; Zhang, J. Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease. Cells 2020, 9, 2293. Meor Azlan, N.F.; Zhang, J. Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease. Cells 2020, 9, 2293.
Abstract
The SLC12 family of cation-chloride-cotransporters (CCCs), comprising potassium chloride cotransporters (KCCs)-mediated Cl- extrusion relative to sodium chloride cotransporters (NKCCs)-mediated Cl- loading, play vital roles in cell volume regulation and ion homeostasis. These functions of the CCCs influence a variety of physiological processes, many of which overlap with the pathophysiology of cardiovascular disease. Although not all of the cotransporters have been linked to Mendelian genetic disorders, recent studies have provided new insights into their functional role in vascular and renal cells along with their contribution to cardiovascular diseases. Particularly, an imbalance in potassium levels promote the pathogenesis of atherosclerosis and disturbances in sodium homeostasis are one of the causes of hypertension. Recent findings even suggest hypothalamic signalling as a key signalling pathway in the pathophysiology of hypertension. In this review, we summarize and discuss the role of CCCs in cardiovascular disease with particular emphasis on knowledge gained in recent years on NKCCs and KCCs.
Keywords
cardiovascular disease; hypertension; atherosclerosis; electroneutral transport; cation-chloride-cotransporters; KCCs; NKCCs
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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