Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Obesity Promotes Glucocorticoid-dependent Muscle Atrophy in Male C57BL/6J Mice.

Version 1 : Received: 17 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (02:38:54 CEST)

How to cite: Gunder, L.C.; Harvey, I.; Redd, J.R.; Davis, C.S.; AL-Tamimi, A.; Brooks, S.V.; Bridges, D. Obesity Promotes Glucocorticoid-dependent Muscle Atrophy in Male C57BL/6J Mice.. Preprints 2020, 2020080419 (doi: 10.20944/preprints202008.0419.v1). Gunder, L.C.; Harvey, I.; Redd, J.R.; Davis, C.S.; AL-Tamimi, A.; Brooks, S.V.; Bridges, D. Obesity Promotes Glucocorticoid-dependent Muscle Atrophy in Male C57BL/6J Mice.. Preprints 2020, 2020080419 (doi: 10.20944/preprints202008.0419.v1).

Abstract

Glucocorticoids promote muscle atrophy by inducing a class of proteins called atrogenes, resulting in reductions in muscle size and strength. In this work, we evaluated whether a mouse model with pre-existing diet-induced obesity had altered glucocorticoid responsiveness. We observed that all animals treated with the synthetic glucocorticoid dexamethasone had reduced strength, but that obesity exacerbated this effect. These changes were concordant with more pronounced reductions in muscle size, particularly in Type II muscle fibers, and potentiated induction of atrogene expression in the obese mice relative to lean mice. Furthermore, we show that the reductions in lean mass do not fully account for the dexamethasone-induced insulin resistance observed in these mice. Together these data suggest that obesity potentiates glucocorticoid-induced muscle atrophy.

Subject Areas

glucocorticoids; atrophy; obesity; atrogenes; insulin resistance

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