Preprint Article Version 1 This version is not peer-reviewed

Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors

Version 1 : Received: 15 July 2020 / Approved: 17 July 2020 / Online: 17 July 2020 (11:05:08 CEST)

How to cite: Alfinito, E.; Beccaria, M.; Ciccarese, M. Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors. Preprints 2020, 2020070378 (doi: 10.20944/preprints202007.0378.v1). Alfinito, E.; Beccaria, M.; Ciccarese, M. Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors. Preprints 2020, 2020070378 (doi: 10.20944/preprints202007.0378.v1).

Abstract

Cytokines are a family of proteins which play a major role in the regulation of immune system, and enter the development of several diseases from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being spent in therapy and diagnosis, producing inhibitory drugs, as well as biosensors for a rapid, poor invasive, and effective detection. In this regards, even more efficient cytokine receptors are under investigation. In this paper we analyze a set of receptors of cytokine IL-6, investigating their topological features by means of a theoretical approach. Our results suggest a topological indicator that may help in the identification of those receptors having the highest complementarity with the protein, a feature expected to ensure a stable binding. Furthermore, we propose and discuss the use of these receptors in an ideal experiment.

Subject Areas

IL-6 cytokine; biosensors; Proteotronics; aptamers; topological analysis

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