Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors

Version 1 : Received: 15 July 2020 / Approved: 17 July 2020 / Online: 17 July 2020 (11:05:08 CEST)

A peer-reviewed article of this Preprint also exists.

Alfinito, E.; Beccaria, M.; Ciccarese, M. Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors. Biosensors 2020, 10, 106. Alfinito, E.; Beccaria, M.; Ciccarese, M. Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors. Biosensors 2020, 10, 106.

Journal reference: Biosensors 2020, 10, 106
DOI: 10.3390/bios10090106

Abstract

Cytokines are a family of proteins which play a major role in the regulation of immune system, and enter the development of several diseases from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being spent in therapy and diagnosis, producing inhibitory drugs, as well as biosensors for a rapid, poor invasive, and effective detection. In this regards, even more efficient cytokine receptors are under investigation. In this paper we analyze a set of receptors of cytokine IL-6, investigating their topological features by means of a theoretical approach. Our results suggest a topological indicator that may help in the identification of those receptors having the highest complementarity with the protein, a feature expected to ensure a stable binding. Furthermore, we propose and discuss the use of these receptors in an ideal experiment.

Subject Areas

IL-6 cytokine; biosensors; Proteotronics; aptamers; topological analysis

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.