Preprint Article Version 1 This version is not peer-reviewed

Analysis of Metabolites Changes on Obstructive Sleep Apnea Patients After Multilevel Sleep Surgery

Version 1 : Received: 14 July 2020 / Approved: 15 July 2020 / Online: 15 July 2020 (09:19:05 CEST)

How to cite: Alterki, A.; Joseph, S.; Thanaraj, T.A.; Al-Khairi, I.; Cherian, P.; Channanath, A.; Sriraman, D.; Ebrahim, M.; Ibrahim, A.; Tiss, A.; Al-Mulla, F.; Abubaker, J.; Abu-Farha, M. Analysis of Metabolites Changes on Obstructive Sleep Apnea Patients After Multilevel Sleep Surgery. Preprints 2020, 2020070327 (doi: 10.20944/preprints202007.0327.v1). Alterki, A.; Joseph, S.; Thanaraj, T.A.; Al-Khairi, I.; Cherian, P.; Channanath, A.; Sriraman, D.; Ebrahim, M.; Ibrahim, A.; Tiss, A.; Al-Mulla, F.; Abubaker, J.; Abu-Farha, M. Analysis of Metabolites Changes on Obstructive Sleep Apnea Patients After Multilevel Sleep Surgery. Preprints 2020, 2020070327 (doi: 10.20944/preprints202007.0327.v1).

Abstract

Background: Obstructive sleep apnea (OSA) is caused by partial or complete obstruction of the upper airways. Corrective surgeries aim at removing obstructions in the nasopharynx, oropharynx, and hypopharynx. OSA is associated with increased risk of various metabolic diseases. Our objective was to evaluate the effect of surgery on the plasma metabolome. Methods: This study included 39 OSA patients who underwent Multilevel Sleep Surgery (MLS). Clinical and anthropometric measures were taken at baseline and 5 months after surgery. Results: The mean Apnea Hypopnea Index (AHI) significantly dropped from 22.0 ± 18.5 events/hour to 8.97 ± 9.57 events/hour (p-Value <0.001). The Epworth’s sleepiness Score (ESS) dropped from 12.8 ± 6.23 to 2.95 ± 2.40 (p-Value <0.001) indicating success of the surgery in treating OSA. Plasma levels of metabolites, phosphocholines (PC) PC.41.5, PC.42.3, ceremide (Cer) Cer.44.0, and triglyceride (TG) TG.53.6, TG.55.6 and TG.56.8 were decreased (p-Value<0.05) whereas lysophosphatidylcholines (LPC) 20.0 and PC.39.3 were increased (p-Value<0.05) after surgery. Conclusion: This study highlights the success of MLS in treating OSA. Treatment of OSA resulted in improvement in metabolic status that was characterized by decreased TG, PCs and Cer metabolites post-surgery indicating that the success of the surgery positively impacted the metabolic status of these patients.

Subject Areas

Obstructive sleep apnea; Metabolomics; Triglycerides; Phosphocholines; Ceramides; Apnea Hypopnea Index; Polysomnography; Lipid metabolism; Multilevel Sleep Surgery

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