Emerging Role of the Integrated Stress Response upon Viral Infection

Yongshu Wu; Xiaodong Qin; Meera Prajapati; Yijing Li; Zhidong Zhang; Yanmin Li

doi:10.20944/preprints202007.0190.v1

Preprint Review Version 1 This version is not peer-reviewed

Version 1 : Received: 8 July 2020 / Approved: 9 July 2020 / Online: 9 July 2020 (12:22:42 CEST)

The integrated stress response (ISR) is an adaptational signaling pathway that is induced in response to different stimuli, such as accumulation of unfolded and misfolded protein, hypoxia, amino acid deprivation, viral infection and ultraviolet light. It has been known that viral infection can activate ISR, but the role of ISR during viral infection is still unclear. In some cases, ISR is a protective mechanism of host cell against infection with virus whilst ISR may be hijacked by viruses for facilitating its replication. In this review, we highlighted recent advances on induction of ISR upon viral infection and the downstream responses involved such as autophagy, apoptosis, formation of stress granules and innate immunity response. We then discussed the molecular mechanism of ISR regulating viral replication and how viruses antagonize this cellular stress response resulting from ISR.

integrated stress response; eIF2α phosphorylation; unfolded protein response; viral replication; host

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Emerging Role of the Integrated Stress Response upon Viral Infection

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