Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis

Lucia Ziccardi
ORCID logo ,
Lucilla Barbano
* ,
Laura Boffa
,
Maria Albanese
,
Andrzej Grzybowski
ORCID logo ,
Benedetto Falsini
,
Diego Centonze
,
Vincenzo Parisi
Version 1 : Received: 6 July 2020 / Approved: 8 July 2020 / Online: 8 July 2020 (11:52:34 CEST)

How to cite: Ziccardi, L.; Barbano, L.; Boffa, L.; Albanese, M.; Grzybowski, A.; Falsini, B.; Centonze, D.; Parisi, V. Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis. Preprints 2020, 2020070152. https://doi.org/10.20944/preprints202007.0152.v1 Ziccardi, L.; Barbano, L.; Boffa, L.; Albanese, M.; Grzybowski, A.; Falsini, B.; Centonze, D.; Parisi, V. Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis. Preprints 2020, 2020070152. https://doi.org/10.20944/preprints202007.0152.v1

Abstract

The involvement of macular function in its preganglionic elements, during the neurodegenerative process of multiple sclerosis (MS), is controversial. In this case-control observational and retrospective study, we assessed multifocal electroretinogram (mfERG) responses from 41 healthy Controls, 41 relapsing-remitting MS patients without optic neuritis (ON) (MS-noON Group), 47 MS patients with ON: 27 with full recovery of high-contrast best corrected visual acuity (BCVA) (MS-ON-G Group) and 20 with poor recovery of BCVA (MS-ON-P Group). MfERG N1 and P1 implicit times (ITs), and N1-P1 response amplitude densities (RADs) were measured from concentric rings (R) with increasing foveal eccentricity: 0-5° (R1), 5-10° (R2), 10-15° (R3), 15-20° (R4), 20- 25° (R5), and from retinal sectors [superior, nasal, inferior and temporal] between 0-15° and 0- 25°. In MS-ON-P Group, mean mfERG RADs detected from R1 (0-5°) and from the central nasal quadrant (0-15°) were significantly reduced (p<0.01) with respect to those of Control, MS-noON and MS-ON-G Groups. No other significant differences between Groups for any mfERG parameters were found. Our results suggest that in MS, exclusively after ON with poor recovery of BCVA, the neurodegenerative process can induce dysfunctional mechanisms involving photoreceptors and bipolar cells of the fovea and of the more central nasal macular area.

Keywords

multiple sclerosis; preganglionic retinal elements; photoreceptors; bipolar cells; multifocal electroretinogram; neurodegeneration

Subject

Medicine and Pharmacology, Ophthalmology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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