Preprint Hypothesis Version 1 This version is not peer-reviewed

The Role of Endocannabinoid System in Sleep Deprivation-Induced Psychosis-Like Symptoms through Hampering Prepulse Inhibition; A Hypothesis

Version 1 : Received: 12 April 2020 / Approved: 14 April 2020 / Online: 14 April 2020 (06:28:23 CEST)

How to cite: Nami, M.; Kamali, A.; Kazemiha, M.; kosagisharaf, R.; Derman, S. The Role of Endocannabinoid System in Sleep Deprivation-Induced Psychosis-Like Symptoms through Hampering Prepulse Inhibition; A Hypothesis. Preprints 2020, 2020040215 (doi: 10.20944/preprints202004.0215.v1). Nami, M.; Kamali, A.; Kazemiha, M.; kosagisharaf, R.; Derman, S. The Role of Endocannabinoid System in Sleep Deprivation-Induced Psychosis-Like Symptoms through Hampering Prepulse Inhibition; A Hypothesis. Preprints 2020, 2020040215 (doi: 10.20944/preprints202004.0215.v1).

Abstract

The interaction between endocannabinoid (eCB) system with in key brain structures such as hippocampus, amygdala and prefrontal cortex and sleep deprivation (SD)-induced psychosis has been less studied. The present hypothesis revolves around the question whether altered chemical dynamics within the eCB system with the resultant impact on cannabinoid receptors in key cortical hubs would impact SD-induced psychosis-like symptoms. Having this investigated research is expected to pave the path towards identifying newer drug targets namely for schizophrenia.

Subject Areas

endocanabinoid system; sleep deprivation; animal models; psychosis-like symptoms; drug development

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