Version 1
: Received: 1 April 2020 / Approved: 3 April 2020 / Online: 3 April 2020 (04:24:52 CEST)
How to cite:
Koyama, T.; Weeraratne, D.; Snowdon, J.L.; Parida, L. Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment. Preprints2020, 2020040024. https://doi.org/10.20944/preprints202004.0024.v1
Koyama, T.; Weeraratne, D.; Snowdon, J.L.; Parida, L. Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment. Preprints 2020, 2020040024. https://doi.org/10.20944/preprints202004.0024.v1
Koyama, T.; Weeraratne, D.; Snowdon, J.L.; Parida, L. Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment. Preprints2020, 2020040024. https://doi.org/10.20944/preprints202004.0024.v1
APA Style
Koyama, T., Weeraratne, D., Snowdon, J.L., & Parida, L. (2020). Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment. Preprints. https://doi.org/10.20944/preprints202004.0024.v1
Chicago/Turabian Style
Koyama, T., Jane L. Snowdon and Laxmi Parida. 2020 "Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment" Preprints. https://doi.org/10.20944/preprints202004.0024.v1
Abstract
New coronavirus (SARS-CoV-2) treatments and vaccines are under development to combat the COVID-19 disease. Several approaches are being used by scientists for investigation including 1) various small molecule approaches targeting RNA polymerase, 3C-like protease, and RNA endonuclease and 2) exploration of antibodies obtained from convalescent plasma from patients who have recovered from COVID-19. The coronavirus genome is highly prone to mutations that lead to genetic drift and escape from immune recognition; thus, it is imperative that sub-strains with different mutations are also accounted for during vaccine development. As the disease has grown to become a pandemic, new B-cell and T-cell epitopes predicted from SARS coronavirus have been reported. Using the epitope information along with variants of the virus, we have found several variants which might cause drifts. Among such variants, 23403A>G variant (p.D614G) in spike protein B-cell epitope is observed frequently in European countries such as the Netherlands, Switzerland and France.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
