Preprint Article Version 1 This version is not peer-reviewed

2019-nCoV: A Possible Progenitor for SARS-CoV with Bat Origin?

Version 1 : Received: 9 March 2020 / Approved: 10 March 2020 / Online: 10 March 2020 (03:49:10 CET)

How to cite: Xu, Y.; Wang, L.; Jia, X.; Feng, Y. 2019-nCoV: A Possible Progenitor for SARS-CoV with Bat Origin?. Preprints 2020, 2020030159 (doi: 10.20944/preprints202003.0159.v1). Xu, Y.; Wang, L.; Jia, X.; Feng, Y. 2019-nCoV: A Possible Progenitor for SARS-CoV with Bat Origin?. Preprints 2020, 2020030159 (doi: 10.20944/preprints202003.0159.v1).

Abstract

A novel coronavirus (2019-nCoV) that is initially found to trigger human severe respiratory illness in Wuhan City of China, 2019, has been recognized as a public health emergency of international concern. In the past two months, this deadly agent has caused 77,785 cases with 2,666 deaths via rapid person-to-person transmission and reached at least 25 countries. However, its evolutionary origin is poorly understood. Here we show integrative evidence that 2019-nCoV is a possible progenitor for SARS-CoV with bat origin. Our finding underscores the importance of tracing origin in the efficient monitoring, and effectively preventing the interspecies transmission of such emerging/re-emerging coronaviruses.

Subject Areas

bat SARS-like CoV; SARS-CoV; 2019-nCoV; phylogeny; spike protein; viral and host fusion

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