Examination of Demographic Characteristics of Drug and Corrosive Poisonings, Morbidity and Mortality in Children in terms of Emergency Department and Pediatric Surgery

Background: Poisoning constitutes an important part of morbidity and mortality among environmental emergencies that can be prevented, frequent in childhood, requiring rapid diagnosis and treatment. This study aimed was to examine the epidemiological, clinical and therapeutic characteristics of drug and corrosive poisonings in terms of children. Materials and Methods: Between January 2010 and December 2018, 1678 patients between the ages of 1-16 who applied to the emergency department with drug and corrosive poisoning were included in the study. The patients were divided into three groups as 1-5, 6-11 and over 12 years of age, and the substances with known pharmacological agents were divided into 10 groups. The Zargar Classification (7) was used to determine the degree of damage caused by corrosive substances in the esophagus. Results: The mean age of the patients was 8.32 ± 3.23 years (1-15 years). The girl/boy ratio of the cases was 1.18 / 1 and 54.3% were girls. 18.9% of the cases were under five years of age, 61% were between 6-11 years and 20% were older than 12 years. 94.6% of the patients were poisoned by drugs and 5.4% of them were poisoned due to non-drug reasons. Accidental poisoning was most commonly seen in children aged 6-11 and suicides were seen in children older than 12 years. It was found that 62.2% of the poisonings were accidental Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 11 February 2020 doi:10.20944/preprints202002.0154.v1 © 2020 by the author(s). Distributed under a Creative Commons CC BY license. and 37.8% were suicidal. The most common causes of poisoning were analgesics and paracetamol exposure as a pharmacological agent. Mortality was found to be most common in 1-5 years age group and accidental poisonings. Accidental poisoning was common in girls and suicidal poisoning was common in boys. Grade 3 damage was found endoscopically in all of the mortalities due to corrosive substances. Conclusion: It was found that accidental poisoning was observed in children under five years of age, suicides were observed in children older than 12 years and the most important cause of mortality was due to corrosive substances. Cause-specific rapid diagnosis and treatment will contribute to the reduction of morbidity and mortality.


Introduction
Poisoning is a condition that kills or damages the organism by the introduction of toxic substances into the body and is among the preventable causes of morbidity and mortality among childhood emergency diseases [1,2].Although the advancing technology, conscious nutrition, and preventive medicine practices become widespread, it still stands out among the causes of death [3].The annual incidence of suicidal or accidental poisoning is between 0.02-0.93% in developed countries and between 0.46-1.57% in developing countries [4].80% of poisonings are in children under 5 years of age.2% of children's deaths in developed countries and more than 5% in developing countries are due to poisoning [5].Drug poisoning, which is one of the important reasons for admission to pediatric emergency departments, is an important problem both in terms of public health and socioeconomics and the admissions with this cause continue to increase around the world.Early diagnosis and treatment are important because of the high morbidity and mortality rates in the late intervention [6].To reduce the morbidity and mortality rates of poisoning cases in the pediatric age group, it is important to take necessary precautions and establish treatment protocols as well as the knowledge of pharmacological characteristics.In this study, we aimed to reveal the effects of drug and non-drug poisonings and to contribute to the future treatment algorithm.

Study Design and Population
A total of 1678 children who were brought to the emergency department with drug poisoning and caustic substance ingestion between January 2010 and December 2018, who underwent outpatient and inpatient follow-up and whose file information could be accessed were included in this retrospective cohort study.Substances with known pharmacological agents were divided into classification was used to determine the degree of damage to the esophagus due to corrosive substance ingestion (Table 1).

Statistical Analysis
The data obtained from this study were analyzed by SPSS  When the relationship between age groups and endoscopic staging of esophageal damage after corrosive substance exposure was examined, grade 1 damage was the most common.Grade 1 damage was most commonly seen in the 6-11 age group.Those taking multiple drugs were not included in single groups (Table 3).Girl patients were more in the accidental poisoning group whereas boy patients were the majority in the SCT group.Patients who were poisoned by multiple agents were more in the SCT group.Analgesic / antipyretic drugs were the leading drugs used for suicidal purposes, followed by antidepressant drugs.25.6% of the patients poisoned by non-drug agents were in the SCT group.Grade 1 damage was found to be the most common in SCT and ACT patients in the endoscopic staging of the damage caused by corrosive poisoning (Table 4).Patients with singleagent exposure constituted the majority of the patients in whom mortality was not observed.While no mortality was observed in the suicide group, all patients in whom mortality was observed were in the ACT group.In the non-mortality group, the three most frequently exposed substances were analgesic /antipyretic drugs (46.2%), antidepressant drugs (20.3%), anti-cardiac drugs (13.1%), while the exposed substances in the mortality group were corrosive (50%), antidiabetic drugs (12.5%), anticardiac drugs (12.5%), analgesic/antipyretic drugs (12.5%) and organophosphates (12.5%).Endoscopic examination of patients in whom mortality was observed due to corrosive substance ingestion included patients of grade 3A and Grade 3B (Table 5).A single variable regression analysis of the causes of poisoning showed that there was a significant prognostic symptom with sex, age, RDW, MPV, blood sugar and drug-induced intoxications.However, only age, RDW, and MPV were associated with the risk of prognosis of drug-induced intoxications after multivariate regression analysis (Table 6).[11,12].
Studies are showing that suicidal poisonings are more common in adolescent girls [13,14].In the study of Tekerek et al. [15], suicidal poisonings were frequently seen in girls and accidental poisonings were frequently seen in boys, whereas most of the poisonings were seen to be accidental.In the literature, suicidal poisoning cases increase with age.Greene reported in his study that suicidal behaviors were not present in those younger than 6 years of age and that suicide was quite rare between the ages of 6-12 [16].In our study, 23.3% of suicidal poisonings were in the range of 6-11 years, 76.7% were patients aged 12 years and older.
Also, no suicidal cases were detected in patients younger than five years of age.The most frequent suicidal poisoning was found in 470 (74%) boys.The most frequent agent used for the suicidal purpose was paracetamol and the second was antidepressants.
Poisoning agents were mostly peroral drugs and cleaning products that were easily accessible to children [17,18].It was reported that the most common poisonings were by paracetamol in separate studies by Kondolot et al. [10,19], by central nervous system drugs in the study by Bucak et al. [20] and by nonsteroidal antiinflammatory agents in the study by Baş et al. [21,22] reported that 71% of poisonings were by drugs and 18.9% were by organophosphate pesticides.It can be thought that the difference in these studies depends on the social structure and life as well as dealing with agriculture.In our study, the most common poisonings were found to be by analgesics/antipyretics (the most common of them was paracetamol) between the ages of 1-5, by antidepressants between the ages of 6-11 and by analgesics/antipyretics over 12 years of age.
The increase in the frequency of antidepressant poisoning may be because the population is more comfortable to consult a doctor for psychiatric disorders and the access of children to antidepressant drugs that are increasingly used as a result of the increase in such problems throughout the society.Poisoning can occur by taking one type of agent or multiple agents at the same time.In a study by Fuller et al. [23], it was found that there was multiple drug ingestion in 50% of all poisoning cases.In the study of Karcıoğlu et al. [24], 53.6% of the poisonings were by single drug and 46.4% were by multiple drugs, whereas in the study of Kaygusuz et al. [25], 41.2% of the cases were poisoned by single drug and 53.5% were by multiple drugs.In our study, it was found that 1031 (61.4) of the patients who were accidentally poisoned were exposed to a single drug, 12 (0.7) of them were exposed to multiple drugs and 412 (24.6) of the suicidal poisonings occurred with single drug exposure, 223 (13.3) of them occurred with single drug exposure.The use of multiple drugs in suicides of children aged 12 years and older are especially noteworthy.The ingestion of corrosive substances is usually of an accidental origin [26].
It was found that children under the age of 5 years constituted a high-risk group in accidental ingestion, it peaked at the age of 2 years, and it was most commonly seen in boys [27].Corrosive esophagitis is the most common condition caused by corrosive substances and stricture develops as the most frequent complication [26].In the study by Koç et al. [28], 40.3% of the cases were evaluated as clinically normal and 63.1% of 46 cases with pathological findings were found to have hyperemia in the oropharynx.In the study of Karaaslan et al. [27], esophagoscopy was performed in 1/4 of the cases and changes were detected in the esophagus ranging from grade 1 to grade 2b.In a study by Kutlu et al. [29], it was observed that the esophagus was affected at different levels in 73.6% of the cases undergoing endoscopy.In our study, poisonings by corrosive substances were found most frequently between the ages of 6-11 and most of them were accidental ingestions.Poisoning by corrosive substances was found to be much lower in our series compared to similar studies (4.2%) [3,10].This may be thought to be the result of public awareness of the potential dangers of children's access to cleaning agents and the fact that they are becoming more careful.
However, the fact that 50% of the deaths in our series is the result of complications due to the ingestion of caustic substance shows that studies should be conducted to raise awareness on this issue.Keeping cleaning agents in a locked place out of the reach of children and extending the use of smart lids in packages containing cleaning agents will be beneficial in preventing poisoning by such substances.While the mortality rate is low in developed countries in poisonings, it is still very high in developing countries.The mortality rate in poisoning cases varies between 0.1% and 3.9% [30].In the United States [31], the mortality rate was reported to be 2% in patients younger than 6 years, 0.06% between 6-12 years and 5.6% between 13-19 years of age.The mortality rate was found as 0.4% in the UK [32].Poisoning-related deaths were reported in 2.5-13.6% in Pakistan [33] and 8.9% in India [34].The rate of poisoning-related deaths in Turkey ranges from 0% to 5% [10].In our study, the mortality rate was 0.5% and the recovery rate was 99.5%.This mortality rate was found to be quite low compared to the studies conducted in our region in the past years [35].
Four of the eight cases in whom mortality was observed were due to corrosive substances and four cases were due to aspirin, antidiabetic, anti-cardiac and organophosphate poisonings.
All of the causes of mortality due to drug poisoning were very late admissions to the hospital.Improvements in diagnosis and treatment may be the main reason for the decrease in mortality rate.Most of the poisonings are asymptomatic and only supportive treatment is provided.However, the main treatment is the implementation of the approach to the emergency patient protocol.
Besides, it is in the form of preventing or reducing the absorption of the active substance, administering systemic antidotes, if any, altering the metabolism of the active substance, accelerating excretion from the body, and treatment according to findings [9].
In the study in Spain, it was reported that 61.3% of the patients were admitted to the hospital within one hour after ingestion of toxic substances, 10.3% were treated before admission, 83.3% were discharged from the emergency department and 15.2% were followed by hospitalization; 1.5% were followed in the intensive care unit [22,36] reported that 87% of patients admitted with poisoning were discharged from the emergency department and mortality was 0.03%.
In our study, similar treatment in the literature was performed in the emergency department [9].To decrease the absorption, gastric lavage was applied to 61% and activated charcoal was applied to 79% of the patients who admitted to the hospital in the first hour.
Also, the systemic antidote for the active substance was given after the first intervention, if any.83% of the cases were hospitalized and the others were followed up in the emergency department.
In patients who came after poisoning by corrosive substance, hyperemia in the oral mucosa which is the first sign of poisoning, inability to swallow saliva, burn marks on the lips and tongue were searched.Endoscopic procedure was applied to patients who gave consent to detect esophageal burn.Grade 0 patients without any burns were discharged without medical treatment.Medical treatment was initiated in patients with burns according to the degree of burn.The degrees of burn were detected as 3A and 3B in 4 patients in whom mortality was observed due to corrosive substances.Careful follow-up and treatment of these patients are necessary as the corrosive substance is an important cause of mortality.It is of utmost importance to take measures to prevent children from accessing these substances and to organize programs to raise awareness of families.The most important constraint in the study was that it was retrospective.Other important constraints were the limited retrieval of information due to the difficulty in reaching data and patient relatives.

Conclusion
Although deaths due to poisoning have decreased in recent years, the increase of poisoning cases is an important health problem.It is thought that the expansion of health care services and easy access are effective in reducing deaths.Because accidental poisonings are in the majority in developing countries and may result in death, we believe that the main solution is education despite the improvements in the diagnosis and treatment of poisonings.It is important for public health that the primary objective is to take measures to prevent poisoning, to raise awareness of the families and to make the use of smart lids compulsory.The effective use of the National Poison Information Centers will ensure faster and more accurate post-poisoning treatment.

Food
and plant poisonings, ingestion of unknown agents, patients without consent for the study, patients under 1 year and above 16 years of age were excluded from the study.The data of the patients were evaluated in terms of age, sex, poisoning agent, provided treatments and prognoses.'Medical records' or other emergency outpatient records, paramedic reports, inpatient charts, nursing notes, and other clinical records.Studies based on death certificates, forensic reports or other public records and all studies based on animal or laboratory research were excluded.Patients poisoned by drug and non-drug agents were divided into three groups as 1-5, 6-11 and over 12 years of age.The causes of poisoning (accidental or suicidal), clinical findings and treatments were recorded.

Table 2 :
Baseline characteristics of study patients.

patients Cause of Poisoning Patients with Accident Suicide
Analgesics were the leading agents responsible for drug poisoning, followed by antidepressants.Paracetamol was the most common poisoning agent in the analgesic group and was most frequently seen between the ages of 6-11.In drug poisonings according to age, it was found that analgesic / antipyretic group poisoning was the most common in all age groups.Antidepressants were the second most common cause of poisoning in the 6-11 -2.131 0.033 Copyright@ Abuzer Coskun | Biomed J Sci & Tech Res | BJSTR.MS.ID.004538.Note: Yr: year, SD: Standard deviation, BS: Blood Sugar , ALT: Alanın Aminotransferaz, AST: Aspartat Aminotransferaz, ALP: Alkalen Fosfataz, CRP: C reactive protein , WBC: White Blood Cell, MCV; Mean Corpuscular Volume; MCH: Mean Corpuscular Hemoglobine; MCHC:Mean Corpuscular Hemoglobin Concentration; RDW: Red cell distrubition width; MPV:Mean Platelate Volum, P: phosphorus, Na+: Sodium, Cl: Chlorine, K + : Potassium, Ca++: Calcium *p<0.05 age group.Non-drug poisonings (organophosphates, corrosive substances) were also most frequently observed between the ages of 6-11.Mortality was most commonly observed in the 1-5 age group and it was observed in 5 (0.3%) patients in this group.

Table 3 :
Chi-square test according to the variables of age groups.

Table 4 :
Chi-square test analysis according to the variables of Cause of Poisoning.

Table 5 :
Chi-square test analysis according to the variables of Mortality.

Table 6 :
Univariate and multivariate Cox regression analyses for predicting the development of cause of poisoning.
[10]ge and the majority of them were boys in the study byAkgül etal.[9]Also,30.7% of the poisoned patients were older than twelve years of age and the majority of them were girls.In contrast, the rate of boys over 12 years of age was found to be high in the study by Kondolot et al.[10]In our study, accidental poisonings were more common in girls, whereas suicidal poisonings were more common in boys.Unlike the literature, this high rate suggests that parents or caregivers being more careful in childcare may cause less accidental poisoning in the under-five age group.This high rate between the ages of 6-11 maybe because children are in an age range where they gain more autonomy and are less controllable.In general, 85-90% of children poisonings were accidental and 10-15% were suicidal