Version 1
: Received: 21 January 2020 / Approved: 24 January 2020 / Online: 24 January 2020 (10:54:30 CET)
Version 2
: Received: 17 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (09:32:07 CEST)
How to cite:
Sorial, A.K.; Anjum, S.A.; Cook, M.J.; Board, T.N.; O'Neill, T.W. Statins, Bone Biology and Revision Arthroplasty: Review of Clinical and Experimental Evidence. Preprints2020, 2020010277. https://doi.org/10.20944/preprints202001.0277.v2
Sorial, A.K.; Anjum, S.A.; Cook, M.J.; Board, T.N.; O'Neill, T.W. Statins, Bone Biology and Revision Arthroplasty: Review of Clinical and Experimental Evidence. Preprints 2020, 2020010277. https://doi.org/10.20944/preprints202001.0277.v2
Sorial, A.K.; Anjum, S.A.; Cook, M.J.; Board, T.N.; O'Neill, T.W. Statins, Bone Biology and Revision Arthroplasty: Review of Clinical and Experimental Evidence. Preprints2020, 2020010277. https://doi.org/10.20944/preprints202001.0277.v2
APA Style
Sorial, A.K., Anjum, S.A., Cook, M.J., Board, T.N., & O'Neill, T.W. (2020). Statins, Bone Biology and Revision Arthroplasty: Review of Clinical and Experimental Evidence. Preprints. https://doi.org/10.20944/preprints202001.0277.v2
Chicago/Turabian Style
Sorial, A.K., Tim N. Board and Terence W. O'Neill. 2020 "Statins, Bone Biology and Revision Arthroplasty: Review of Clinical and Experimental Evidence" Preprints. https://doi.org/10.20944/preprints202001.0277.v2
Abstract
Osteoarthritis is a painful, disabling condition which is increasing in prevalence as a result of an ageing population. With no recognised disease limiting therapeutics, arthroplasty of the hip and knee is the most common and effective treatment for lower limb osteoarthritis, however lower limb arthroplasty has a finite life-span and a proportion of patients will require revision arthroplasty. With increasing life expectancy and an increasing proportion of younger (<65 years) patients undergoing arthroplasty, the demand for revision arthroplasty after implant failure is also set to increase. Statins are cholesterol modulating drugs widely used for cardiovascular risk reduction which have been noted to have pleiotropic effects including potentially influencing arthroplasty survival. In vitro studies have demonstrated pleiotropic effects in human bone cells, including enhancement of osteoblastogenesis following simvastatin exposure, and in vivo studies have demonstrated that intraperitoneal simvastatin can increase peri-implant bone growth in rats following titanium tibial implant insertion. There is evidence also that statins may also influence osseointegration, enhancing bone growth at the bone-implant interface, subsequently improving the functional survival of implants. Data from the Danish Hip Arthroplasty Registry and Clinical Practice Research Datalink in the UK suggest a reduction in the risk of lower limb revision arthroplasty in statin ever-users vs never users, and a time dependent effect of statin administration on reduction in risk of revision. In this article we review the clinical and scientific evidence linking statins and risk of revision arthroplasty.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Antony Kameel Sorial
Commenter's Conflict of Interests: Author