Garofalo P, Suri HS, Porcu M, Suri JS, Saba L (2020) White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance. J Non Invasive Vasc Invest 5: 017.
Garofalo P, Suri HS, Porcu M, Suri JS, Saba L (2020) White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance. J Non Invasive Vasc Invest 5: 017.
Garofalo P, Suri HS, Porcu M, Suri JS, Saba L (2020) White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance. J Non Invasive Vasc Invest 5: 017.
Garofalo P, Suri HS, Porcu M, Suri JS, Saba L (2020) White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance. J Non Invasive Vasc Invest 5: 017.
Abstract
“White matter disease” identifies series of different conditions and pathological mechanisms: autoimmune, infectious, toxic-metabolic and vascular. Each of these leads to a global impairment of the neural myelination process through the secondary destruction of previously myelinated structures. To date, the imaging spectrum represents an irreplaceable tool to detect these lesions, describe their distribution patterns and stage them over time. This study aims presents a pictorial review of white matter disease, from pathology to imaging spectrum, reporting current main staging systems with greater emphasis to relationship between cerebrovascular disease and white matter hyper-intensity appearance, and the newest advances in this field.
Keywords
computed tomography (CT); magnetic resonance imaging (MRI); leukoaraiosis (LA); white matter hyperintensities (WMH); small vessels disease (SVD); periventricular white matter hyperintensities (PWMH); deep white matter hyperintensities (DWMH)
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
