Preprint Review Version 1 This version is not peer-reviewed

White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance

Version 1 : Received: 4 January 2020 / Approved: 5 January 2020 / Online: 5 January 2020 (16:11:25 CET)

A peer-reviewed article of this Preprint also exists.

Garofalo P, Suri HS, Porcu M, Suri JS, Saba L (2020) White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance. J Non Invasive Vasc Invest 5: 017. Garofalo P, Suri HS, Porcu M, Suri JS, Saba L (2020) White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance. J Non Invasive Vasc Invest 5: 017.

Journal reference: Journal of Non Invasive Vascular Investigation 2020
DOI: 10.24966/NIVI-7400/100017

Abstract

“White matter disease” identifies series of different conditions and pathological mechanisms: autoimmune, infectious, toxic-metabolic and vascular. Each of these leads to a global impairment of the neural myelination process through the secondary destruction of previously myelinated structures. To date, the imaging spectrum represents an irreplaceable tool to detect these lesions, describe their distribution patterns and stage them over time. This study aims presents a pictorial review of white matter disease, from pathology to imaging spectrum, reporting current main staging systems with greater emphasis to relationship between cerebrovascular disease and white matter hyper-intensity appearance, and the newest advances in this field.

Subject Areas

computed tomography (CT); magnetic resonance imaging (MRI); leukoaraiosis (LA); white matter hyperintensities (WMH); small vessels disease (SVD); periventricular white matter hyperintensities (PWMH); deep white matter hyperintensities (DWMH)

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