Preprint Article Version 1 This version is not peer-reviewed

Short Tear Break-Up Time and Seasonal Variation in Intra-Ocular Pressure

Version 1 : Received: 28 December 2019 / Approved: 29 December 2019 / Online: 29 December 2019 (09:17:39 CET)

How to cite: Ayaki, M.; Negishi, K.; Yuki, K.; Kawashima, M.; Uchino, M.; Tsubota, K. Short Tear Break-Up Time and Seasonal Variation in Intra-Ocular Pressure. Preprints 2019, 2019120376 (doi: 10.20944/preprints201912.0376.v1). Ayaki, M.; Negishi, K.; Yuki, K.; Kawashima, M.; Uchino, M.; Tsubota, K. Short Tear Break-Up Time and Seasonal Variation in Intra-Ocular Pressure. Preprints 2019, 2019120376 (doi: 10.20944/preprints201912.0376.v1).

Abstract

Purpose: To evaluate seasonal variation in intra-ocular pressure (IOP) with and without short tear break-up time (SBUT, BUT ≤ 5 s). Methods: This study enrolled 176 patients who visited one of six eye clinics in Japan for IOP measurement at every season. The mean patient age was 67.9 years, including 79 males. We compared the seasonal variation in IOP (mean ± SD) across spring (Mar-May), summer (Jun-Aug), fall (Sep-Nov), and winter (Dec-Feb). Results: The IOP (mmHg) in winter and summer, respectively, was 12.8 ± 3.7 and 12.8 ± 3.1 for non-glaucoma patients without SBUT (n = 47, P = 0.964), 14.8 ± 3.4 and 13.3 ± 3.4 for non-glaucoma patients with SBUT (n = 57, P < 0.001), 14.3 ± 3.2 and 14.1 ± 3.4 for glaucoma patients without SBUT (n = 36, P = 0.489), and 13.3 ± 3.0 and 11.6 ± 2.9 for glaucoma with SBUT (n = 36, P < 0.001). Seasonal variation was largest across the seasons in the glaucoma with SBUT group, and the magnitude of seasonal variation correlated with BUT (β = 0.228, P = 0.003). Conclusions: Seasonal variation tended to be larger in patients with SBUT than those without SBUT.

Subject Areas

dry eye; tear break-up time; intra-ocular pressure; seasonality

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