Version 1
: Received: 15 December 2019 / Approved: 16 December 2019 / Online: 16 December 2019 (11:12:15 CET)
How to cite:
Hong, Y.A.; Han, K.; Yun, J.; Koh, E.S.; Ko, S.; Chung, S. Association of Short Stature with An Increased Risk of End-Stage Renal Disease in Type 2 Diabetic Patients: A Nationwide Population-Based Cohort Study. Preprints2019, 2019120213. https://doi.org/10.20944/preprints201912.0213.v1
Hong, Y.A.; Han, K.; Yun, J.; Koh, E.S.; Ko, S.; Chung, S. Association of Short Stature with An Increased Risk of End-Stage Renal Disease in Type 2 Diabetic Patients: A Nationwide Population-Based Cohort Study. Preprints 2019, 2019120213. https://doi.org/10.20944/preprints201912.0213.v1
Hong, Y.A.; Han, K.; Yun, J.; Koh, E.S.; Ko, S.; Chung, S. Association of Short Stature with An Increased Risk of End-Stage Renal Disease in Type 2 Diabetic Patients: A Nationwide Population-Based Cohort Study. Preprints2019, 2019120213. https://doi.org/10.20944/preprints201912.0213.v1
APA Style
Hong, Y.A., Han, K., Yun, J., Koh, E.S., Ko, S., & Chung, S. (2019). Association of Short Stature with An Increased Risk of End-Stage Renal Disease in Type 2 Diabetic Patients: A Nationwide Population-Based Cohort Study. Preprints. https://doi.org/10.20944/preprints201912.0213.v1
Chicago/Turabian Style
Hong, Y.A., Seung-Hyun Ko and Sungjin Chung. 2019 "Association of Short Stature with An Increased Risk of End-Stage Renal Disease in Type 2 Diabetic Patients: A Nationwide Population-Based Cohort Study" Preprints. https://doi.org/10.20944/preprints201912.0213.v1
Abstract
Short stature has been associated with increased various disease and all-cause death, but no reliable data exist the association between height and end-stage renal disease (ESRD) in diabetic patients. We investigated the relationship between short stature, development of ESRD, and mortality in type 2 diabetes. This study analyzed clinical data using the National Health Insurance Database in Korea. Height was stratified by five groups according to age and sex. Risk of ESRD and all-cause mortality was analyzed with Cox proportional hazards models. During a 6.9-year follow-up period, 220,457 subjects (8.4%) died and 28,704 subjects (1.1%) started dialysis. Short stature significantly increased the incidence of ESRD and all-cause mortality in the overall cohort analysis. In multivariable analysis, hazard ratios (HR) for development of ESRD comparing the highest versus lowest quartiles of adult height were 0.86 (95% confidence interval (CI), 0.83–0.89). All-cause mortality also decreased with highest height compared to patients with lowest height after fully adjusting for confounding variables (HR 0.79, 95% CI, 0.78–0.81). Adult height had an inverse relationship with newly diagnosed ESRD and all-cause in both males and females. Short stature is strongly associated with an increased risk of ESRD and all-cause mortality in type 2 diabetes.
Keywords
short stature; type 2 diabetes; end-stage renal disease; mortality
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
