Preprint Article Version 1 This version is not peer-reviewed

Estimation of Serum Chemerin, Visfatin Levels and Their Ratio as A Possible Diagnostic Parameters of Rheumatoid Arthritis

Version 1 : Received: 27 October 2019 / Approved: 29 October 2019 / Online: 29 October 2019 (09:31:13 CET)

How to cite: Mohammed Ali, D.M.; Al-Fadhel, S.Z.; Al-Ghuraibawi, N.H.A.; Al-Hakeim, H.K. Estimation of Serum Chemerin, Visfatin Levels and Their Ratio as A Possible Diagnostic Parameters of Rheumatoid Arthritis. Preprints 2019, 2019100324 (doi: 10.20944/preprints201910.0324.v1). Mohammed Ali, D.M.; Al-Fadhel, S.Z.; Al-Ghuraibawi, N.H.A.; Al-Hakeim, H.K. Estimation of Serum Chemerin, Visfatin Levels and Their Ratio as A Possible Diagnostic Parameters of Rheumatoid Arthritis. Preprints 2019, 2019100324 (doi: 10.20944/preprints201910.0324.v1).

Abstract

Objective: Rheumatoid Arthritis (RA) is a chronic inflammatory disease affecting the synovium and articular cartilage that initiates joint damage. RA associates with a change in many inflammatory biomarkers. The present study aims to measure the levels of inflammatory adipocytokines (chemerin and visfatin) and their ratio in addition to some related biomarkers in RA patients group in comparison to healthy control group and find out their efficacy in diagnosis of RA.Methods: The study included 60 RA patients and 30 healthy control group. Serum visfatin and chemerin were measured by using ELISA technique, while other biomarkers were determined spectrophotometrically. Multivariate general linear model analysis and Receiver operating curve was used to study the opportunity of using chemerin and visfatin as diagnostic tools for RA.Results: The results indicated that there was a significant increase (p<0.05) in all lipid profile components, except HDLc that decreased, in RA patients in comparison with healthy control group; while significant decrease (p<0.001) in high density lipoprotein-cholesterol of RA patients in comparison with control group. Serum chemerin, visfatin, C-reactive protein, and uric acid levels were significantly higher (p<0.05) in RA patients than those of control group. The results showed a relatively good sensitivity and specificity of chemerin (sensitivity=88.1, specificity=75.9) at a concentration=187.88ng in diagnosis of RA.Conclusions: chemerin is able to diagnose RA efficiently but this diagnoses, due to relatively small specificity, may interfere with other inflammatory disorders. However, with adjuvant with other diagnostic parameters, chemerin may represent a useful addition in diagnosis of RA.

Subject Areas

Rheumatoid Arthritis; chemerin; visfatin; CRP; uric acid

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