Buchberger, E.; Reis, M.; Lu, T.-H.; Posnien, N. Cloudy with a Chance of Insights: Context Dependent Gene Regulation and Implications for Evolutionary Studies. Genes2019, 10, 492.
Buchberger, E.; Reis, M.; Lu, T.-H.; Posnien, N. Cloudy with a Chance of Insights: Context Dependent Gene Regulation and Implications for Evolutionary Studies. Genes 2019, 10, 492.
Buchberger, E.; Reis, M.; Lu, T.-H.; Posnien, N. Cloudy with a Chance of Insights: Context Dependent Gene Regulation and Implications for Evolutionary Studies. Genes2019, 10, 492.
Buchberger, E.; Reis, M.; Lu, T.-H.; Posnien, N. Cloudy with a Chance of Insights: Context Dependent Gene Regulation and Implications for Evolutionary Studies. Genes 2019, 10, 492.
Abstract
Research in various fields of evolutionary biology has shown that divergence in gene expression is a key driver for phenotypic variation. An exceptional contribution of cis-regulatory evolution has for instance been found to contribute to morphological diversification. In the light of these findings, the analysis of genome-wide expression data has become one of the central tools to link genotype and phenotype information on a more mechanistic level. However, in many studies, especially if general conclusions are drawn from such data, a key feature of gene regulation is often neglected. With our article, we want to raise awareness that gene regulation and thus gene expression is highly context dependent. Genes show tissue- and developmental stage-specific expression. We argue that the regulatory context must be considered when studying evolution of gene expression.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
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