Preprint Review Version 1 This version is not peer-reviewed

Cloudy with a Chance of Insights: Context Dependent Gene Regulation and Implications for the Evolution of Gene Expression

Version 1 : Received: 24 May 2019 / Approved: 28 May 2019 / Online: 28 May 2019 (10:29:26 CEST)

A peer-reviewed article of this Preprint also exists.

Buchberger, E.; Reis, M.; Lu, T.-H.; Posnien, N. Cloudy with a Chance of Insights: Context Dependent Gene Regulation and Implications for Evolutionary Studies. Genes 2019, 10, 492. Buchberger, E.; Reis, M.; Lu, T.-H.; Posnien, N. Cloudy with a Chance of Insights: Context Dependent Gene Regulation and Implications for Evolutionary Studies. Genes 2019, 10, 492.

Journal reference: Genes 2019, 10, 492
DOI: 10.3390/genes10070492

Abstract

Research in various fields of evolutionary biology has shown that divergence in gene expression is a key driver for phenotypic variation. An exceptional contribution of cis-regulatory evolution has for instance been found to contribute to morphological diversification. In the light of these findings, the analysis of genome-wide expression data has become one of the central tools to link genotype and phenotype information on a more mechanistic level. However, in many studies, especially if general conclusions are drawn from such data, a key feature of gene regulation is often neglected. With our article, we want to raise awareness that gene regulation and thus gene expression is highly context dependent. Genes show tissue- and developmental stage-specific expression. We argue that the regulatory context must be considered when studying evolution of gene expression.

Subject Areas

gene expression; gene regulation; evolution; allele specific expression; eQTL; RNAseq; ChIPseq; chromatin; ATACseq; genotype-phenotype map

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