Preprint Article Version 1 This version is not peer-reviewed

PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery

Version 1 : Received: 6 April 2019 / Approved: 8 April 2019 / Online: 8 April 2019 (08:35:46 CEST)

A peer-reviewed article of this Preprint also exists.

Chen, M.; Feng, X.; Xu, W.; Wang, Y.; Yang, Y.; Jiang, Z.; Ding, J. PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery. Molecules 2019, 24, 1538. Chen, M.; Feng, X.; Xu, W.; Wang, Y.; Yang, Y.; Jiang, Z.; Ding, J. PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery. Molecules 2019, 24, 1538.

Journal reference: Molecules 2019, 24, 1538
DOI: 10.3390/molecules24081538

Abstract

In recent years, polyureas with dynamic hindered urea bonds (HUBs), as a class of promising biomedical polymers, have attracted attention as a benefit of their controlled hydrolytic property. The effect of the chemical structures on the properties of polyureas and their assemblies was rarely reported. In this study, four kinds of polyureas with different chemical groups have been synthesized, and the polyurea from cyclohexyl diisocyanate and tert-butyl diamine showed the fastest hydrolytic rate. The amphiphilic polyurea composed of hydrophobic cyclohexyl-tert-butyl polyurea and hydrophilic poly(ethylene glycol) was synthesized for controlled delivery of antitumor drug paclitaxel (PTX). The PTX-loaded PEGylated polyurea micelle more effectively entered into the murine breast cancer 4T1 cells and inhibited the corresponding tumor growth in vitro and in vivo. Therefore, the PEGylated polyurea with adjustable degradation might be a promising polymer matrix for drug delivery.

Subject Areas

amphiphilc copolymer; hydrolyzable polyurea; micelle; controlled drug delivery; cancer chemotherapy

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