Preprint Article Version 1 This version is not peer-reviewed

Investigation of the Synergistic Toxicity of Binary Mixtures of Pesticides and Pharmaceuticals on Aliivibrio fischeri in Major River Basins in South Korea

Version 1 : Received: 6 December 2018 / Approved: 6 December 2018 / Online: 6 December 2018 (11:08:43 CET)

A peer-reviewed article of this Preprint also exists.

Baek, I.-H.; Kim, Y.; Baik, S.; Kim, J. Investigation of the Synergistic Toxicity of Binary Mixtures of Pesticides and Pharmaceuticals on Aliivibrio fischeri in Major River Basins in South Korea. Int. J. Environ. Res. Public Health 2019, 16, 208. Baek, I.-H.; Kim, Y.; Baik, S.; Kim, J. Investigation of the Synergistic Toxicity of Binary Mixtures of Pesticides and Pharmaceuticals on Aliivibrio fischeri in Major River Basins in South Korea. Int. J. Environ. Res. Public Health 2019, 16, 208.

Journal reference: Int. J. Environ. Res. Public Health 2019, 16, 208
DOI: 10.3390/ijerph16020208

Abstract

This work introduced the potential synergistic toxicity of binary mixtures of pesticides and pharmaceuticals, which have been substantially detected in major river basins in South Korea. Different dose-response curve functions were employed in each experimental toxicity dataset for Aliivibrio fischeri. We tested the toxicity of 30 binary mixtures at two effect concentrations: high effect concentration [EC50] and low effect concentration [EC10] ranges. Thus, the toxicological interactions were evaluated at 60 effected concentration data points in total and based on model deviation ratios (MDRs) between predicted and observed toxicity values (e.g., three types of combined effects: synergistic (MDR > 2), additive (0.5 ≤ MDR ≤ 2), and antagonistic (MDR < 0.5)). From the 60 data points, MDRs could not be applied to 17 points, since their toxicities could not be measured. The result showed 48 %-additive (n = 20), 40 %-antagonistic (n = 17), and 12 %-synergistic (n = 6) toxicity effects from 43 binaries (excluding the 17 combinations without MDRs). In this study, EC10 ratio mixtures at a low overall effect range showed a general tendency to have more synergistic effects than the EC50 ratio mixtures at a high effect range. We also found an inversion phenomenon, which detected three binaries of the combination of synergism at low concentrations and additive antagonism at high concentrations.

Subject Areas

mixture toxicity; concentration addition; pesticide; pharmaceuticals; Aliivibrio fischeri

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