Preprint Review Version 1 This version is not peer-reviewed

A Homeostasis Breakdown Model of Subjective Cognitive Decline

Version 1 : Received: 31 October 2018 / Approved: 2 November 2018 / Online: 2 November 2018 (07:17:11 CET)

A peer-reviewed article of this Preprint also exists.

Mizuno, A.; Ly, M.; Aizenstein, H.J. A Homeostatic Model of Subjective Cognitive Decline. Brain Sci. 2018, 8, 228. Mizuno, A.; Ly, M.; Aizenstein, H.J. A Homeostatic Model of Subjective Cognitive Decline. Brain Sci. 2018, 8, 228.

Journal reference: Brain Sci. 2018, 8, 228
DOI: 10.3390/brainsci8120228

Abstract

Subjective Cognitive Decline (SCD) is a possible earliest detectable sign of dementia, but we do not know what mental processes lead to elevated concern. We summarize the previous literature on the biomarkers and functional neuroanatomy of SCD. To extend the current most-popular theory of SCD, compensatory hyperactivition, we introduce a new model: breakdown of homeostasis in the prediction error minimization system. A cognitive prediction error is a discrepancy between an implicit cognitive predictions and the corresponding outcome. Experiencing frequent prediction errors may be a primary source of elevated subjective concern. Our homeostasis breakdown model explains the progression both from normal cognition to SCD and from SCD to advanced dementia stages.

Subject Areas

subjective cognitive decline; preclinical dementia; fMRI; compensation

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