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A Homeostasis Breakdown Model of Subjective Cognitive Decline
Version 1
: Received: 31 October 2018 / Approved: 2 November 2018 / Online: 2 November 2018 (07:17:11 CET)
A peer-reviewed article of this Preprint also exists.
Mizuno, A.; Ly, M.; Aizenstein, H.J. A Homeostatic Model of Subjective Cognitive Decline. Brain Sci. 2018, 8, 228. Mizuno, A.; Ly, M.; Aizenstein, H.J. A Homeostatic Model of Subjective Cognitive Decline. Brain Sci. 2018, 8, 228.
Abstract
Subjective Cognitive Decline (SCD) is a possible earliest detectable sign of dementia, but we do not know what mental processes lead to elevated concern. We summarize the previous literature on the biomarkers and functional neuroanatomy of SCD. To extend the current most-popular theory of SCD, compensatory hyperactivition, we introduce a new model: breakdown of homeostasis in the prediction error minimization system. A cognitive prediction error is a discrepancy between an implicit cognitive predictions and the corresponding outcome. Experiencing frequent prediction errors may be a primary source of elevated subjective concern. Our homeostasis breakdown model explains the progression both from normal cognition to SCD and from SCD to advanced dementia stages.
Keywords
subjective cognitive decline; preclinical dementia; fMRI; compensation
Subject
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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