Preprint Article Version 1 This version is not peer-reviewed

Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications

Version 1 : Received: 25 October 2018 / Approved: 25 October 2018 / Online: 25 October 2018 (06:20:41 CEST)

A peer-reviewed article of this Preprint also exists.

Ribeiro, S.; Ribeiro, T.; Ribeiro, C.; Correia, D.M.; Farinha, J.P.S.; Gomes, A.C.; Baleizão, C.; Lanceros-Méndez, S. Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications. Nanomaterials 2018, 8, 933. Ribeiro, S.; Ribeiro, T.; Ribeiro, C.; Correia, D.M.; Farinha, J.P.S.; Gomes, A.C.; Baleizão, C.; Lanceros-Méndez, S. Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications. Nanomaterials 2018, 8, 933.

Journal reference: Nanomaterials 2018, 8, 933
DOI: 10.3390/nano8110933

Abstract

Poly(vinylidene fluoride) nanocomposites processed with different morphologies, such as porous and non-porous films and fibres, have been prepared with silica nanoparticles (SiNPs) of varying diameter (17, 100, 160 and 300 nm) which in turn have encapsulated perylenediimide (PDI), a fluorescent molecule. Structural, morphological, optical, thermal, and mechanical properties of the nanocomposites, with SiNP filler concentration up to 16 wt% were evaluated. Further, cytotoxicity and cell proliferation studies were performed. All SiNPs are negatively charged independently of the pH and more stable from pH 5 upwards. The SiNPs introduction within the polymer matrix increases the contact angle independently of the nanoparticle diameters and the smallest ones (17 nm) improve the PVDF Young modulus from 0.94 ± 0.04 GPa for the pristine polymer film to 1.05 ± 0.06 GPa. Varying filler diameter, physico-chemical, thermal and mechanical properties of the polymer matrix were not significantly affected. Finally, the SiNPs inclusion does not induce cytotoxicity in murine myoblasts (C2C12) after 72 h of contact and proliferation studies reveal that the prepared composites represent a suitable platform for tissue engineering applications, as they allow to combine the biocompatibility and piezoelectricity of the polymer with the possible functionalization and drug encapsulation and release of the SiNP.

Subject Areas

nano-structures; polymer-matrix composites (PMCs); mechanical properties; thermal properties

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