Preprint Review Version 1 This version is not peer-reviewed

A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012

Version 1 : Received: 16 October 2018 / Approved: 17 October 2018 / Online: 17 October 2018 (16:52:04 CEST)

How to cite: Muża, M.; Konieczna, L.; Bączek, T. A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012. Preprints 2018, 2018100390 (doi: 10.20944/preprints201810.0390.v1). Muża, M.; Konieczna, L.; Bączek, T. A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012. Preprints 2018, 2018100390 (doi: 10.20944/preprints201810.0390.v1).

Abstract

Exhaled breath condensate (EBC) sample analysis is an entirely non-invasive novel sample collection method that is fast, easy to perform, and effort-appeared independent. EBC samples can be very useful in identifying the biomarkers of many diseases. This review provides an updated overview of EBC pH disturbances in different disorders as well as physiological levels among healthy individuals since 2012. Our meta-analysis addresses some of the key questions related to sample processing before pH measurement and discusses various methods of condensate standardization that can be employed prior to conducting a pH assay. Given the recent widespread interest in research into the use of EBC to identify biomarkers, it is necessary to establish a pathway leading from analytical methods for biomarker evaluation using EBC pH to clinical applications of this technology. This review fills a gap in the literature and attempts to connect theory to practical analytical approaches to analyzing EBC samples and making critical treatment-related decisions next to the patient's bed.

Subject Areas

Exhaled Breath Condensate (EBC) Samples; Noninvasive Colleting Method; Biomarker, Diseases, pH, acidification

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