Preprint Review Version 1 This version is not peer-reviewed

The Expanding Role of Radiosurgery for Brain Metastases

Version 1 : Received: 23 July 2018 / Approved: 24 July 2018 / Online: 24 July 2018 (11:47:15 CEST)

A peer-reviewed article of this Preprint also exists.

O’Beirn, M.; Benghiat, H.; Meade, S.; Heyes, G.; Sawlani, V.; Kong, A.; Hartley, A.; Sanghera, P. The Expanding Role of Radiosurgery for Brain Metastases. Medicines 2018, 5, 90. O’Beirn, M.; Benghiat, H.; Meade, S.; Heyes, G.; Sawlani, V.; Kong, A.; Hartley, A.; Sanghera, P. The Expanding Role of Radiosurgery for Brain Metastases. Medicines 2018, 5, 90.

Journal reference: Medicines 2018, 5, 90
DOI: 10.3390/medicines5030090

Abstract

Stereotactic radiosurgery (SRS) has become increasingly important in the management of brain metastases due to improving systemic disease control and rising incidence. Initial trials demonstrated SRS with whole brain radiotherapy (WBRT) improved local control rates versus WBRT alone. Concerns with WBRT associated neurocognitive toxicity have contributed to greater use of SRS alone, including for patients with multiple metastases and following surgical resection. Molecular information, targeted agents and immunotherapy have also altered the landscape for the management of brain metastases. This review summarises current and emerging data on the role of SRS in the management of brain metastases.

Subject Areas

stereotactic radiosurgery (SRS); stereotactic radiotherapy (SRT); brain metastasis; immunotherapy; whole brain radiotherapy (WBRT)

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