Preprint Article Version 1 This version is not peer-reviewed

Oral Capsinoids Supplementation May not Enhance Glycogen Recovery against Exercise-Induced Loss in Exercised Human Skeletal Muscle

Version 1 : Received: 23 July 2018 / Approved: 23 July 2018 / Online: 23 July 2018 (10:38:14 CEST)

How to cite: Taso, J.; Liao, S.; Shiau, D.; Wu, M.; Chang, C.; Korivi, M.; Cheng, I. Oral Capsinoids Supplementation May not Enhance Glycogen Recovery against Exercise-Induced Loss in Exercised Human Skeletal Muscle. Preprints 2018, 2018070411 (doi: 10.20944/preprints201807.0411.v1). Taso, J.; Liao, S.; Shiau, D.; Wu, M.; Chang, C.; Korivi, M.; Cheng, I. Oral Capsinoids Supplementation May not Enhance Glycogen Recovery against Exercise-Induced Loss in Exercised Human Skeletal Muscle. Preprints 2018, 2018070411 (doi: 10.20944/preprints201807.0411.v1).

Abstract

We investigated whether post-exercise capsinoids (CSN) supplementation could enhance muscle glycogen resynthesis via GLUT4/Akt expressions in human skeletal muscle. Nine male college students (aged 21.4±0.2 years, BMI 21.9±1.3 kg/m2, VO2max 47.1±1.8 ml/kg/min) participated in this crossover designed study, and completed a 60-min cycling exercise at 70% VO2max. Immediately after exercise, participants consumed high-carbohydrate diet (2 g carb/kg bodyweight) with CSN (12 mg, single dosage) or placebo. Biopsied muscle samples (vastus lateralis) were obtained immediately (0h) and 3h after exercise. Blood and expired gas samples were collected before and after exercise. We found oral CSN supplementation immediately after exercise was unable to enhance glycogen resynthesis in exercised human skeletal muscle. Despite, CSN could alter the energy reliance on fat oxidation during post-exercise recovery, based on gaseous exchange measurement (NEFA and glycerol). We further identified no significant differences in postprandial glucose/insulin area under curve in both trials. Western blot data showed no significant response of p-Akt/Akt ratio with CSN during post-exercise recovery. Inconsistent with glycogen levels, muscle GLUT4 expression was significantly elevated at 3h in CSN trial. Our findings emphasize the necessity of further evidences to confirm the ergogenic properties of CSN in connection with glycogen recovery in exercised human skeletal muscle.

Subject Areas

ergogenic aid; muscle glycogen; substrate oxidation; GLUT4

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