Version 1
: Received: 28 June 2018 / Approved: 29 June 2018 / Online: 29 June 2018 (11:36:18 CEST)
How to cite:
Ibrahim, S.; Yahya, F.; gezawa, I.; kabir, N.; Imam, A.; Chedi, B. GC-MS and Heavy Metal Analysis of GASCA D Herbal Formulation. Preprints2018, 2018060483. https://doi.org/10.20944/preprints201806.0483.v1
Ibrahim, S.; Yahya, F.; gezawa, I.; kabir, N.; Imam, A.; Chedi, B. GC-MS and Heavy Metal Analysis of GASCA D Herbal Formulation. Preprints 2018, 2018060483. https://doi.org/10.20944/preprints201806.0483.v1
Ibrahim, S.; Yahya, F.; gezawa, I.; kabir, N.; Imam, A.; Chedi, B. GC-MS and Heavy Metal Analysis of GASCA D Herbal Formulation. Preprints2018, 2018060483. https://doi.org/10.20944/preprints201806.0483.v1
APA Style
Ibrahim, S., Yahya, F., gezawa, I., kabir, N., Imam, A., & Chedi, B. (2018). GC-MS and Heavy Metal Analysis of GASCA D Herbal Formulation. Preprints. https://doi.org/10.20944/preprints201806.0483.v1
Chicago/Turabian Style
Ibrahim, S., Abdulkadir Imam and Bashir Chedi. 2018 "GC-MS and Heavy Metal Analysis of GASCA D Herbal Formulation" Preprints. https://doi.org/10.20944/preprints201806.0483.v1
Abstract
Gasca D herbal formulation is an antidiabetic medicine for the management of diabetes mellitus produced exclusively from natural ingredients. The level of some essential elements (Copper, chromium, Cobalt, Iron, Manganese, Nickel and zinc) and toxic (Cadmium, Arsenic, Mercury, and Lead) heavy metals were determined using microwave plasma-atomic emission spectrometry (MP-AES). The aim of this study is to evaluate the levels of essential and toxic heavy metals and also identify bioactive compounds present in Gasca D herbal formulation. The result shows no traces of Lead, Mercury, Zinc, Arsenic and Zinc, Iron was found to have highest concentration 67.16 + 7.5 µg/g and Cadmium lowest concentration 0.4 + 0.03µg/g. GC-MS analysis of Gasca D herbal formulation revealed the presence of 14 biologically active compounds which include N-Formyl-beta-alanine, Paromomycin, 3,4-Altrosan, Benzamide, 1,3,4-Thiadiazol-2-amine, Carbamodithioic acid, Carbonic acid, alpha-D-Glucopyranoside, Ethyl isocyanide, 2-Propanesulfinic acid, Propanamide, 2-Butenenitrile, Dicyclopropyl carbinol, Isoxazolidine, 1,5-Hexadiene 10-Azido-1-decanethiol. Conclusion: The result indicates that the mean levels of toxic metals in Gasca D herbal formulation were below WHO permissible levels. Gasca D herbal formulation also contains various bioactive compounds that can have various medicinal application which can be used for the treatment of various diseases.
Keywords
Heavy metal, herbal, diabetes
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
