Preprint Review Version 1 This version is not peer-reviewed

Ceftaroline, an Update

Version 1 : Received: 12 June 2018 / Approved: 13 June 2018 / Online: 13 June 2018 (12:04:22 CEST)

How to cite: Lounsbury, N.; Reeber, M.; Mina, G.; Chbib, C. Ceftaroline, an Update. Preprints 2018, 2018060213 (doi: 10.20944/preprints201806.0213.v1). Lounsbury, N.; Reeber, M.; Mina, G.; Chbib, C. Ceftaroline, an Update. Preprints 2018, 2018060213 (doi: 10.20944/preprints201806.0213.v1).

Abstract

Objective: The objective of this review is to describe the outcomes of patients treated with ceftaroline in non-Food and Drug Administration (FDA) approved indications in pediatric or adult populations with infections caused by MRSA. Data sources: A systematic overview was conducted by searching PubMed, Medline, and The Cochrane Library up to October 2017. Study selection and data extraction: All English-language clinical trials and case reports related to the efficacy of ceftaroline in new, not yet approved FDA indications in methicillin-resistant Staphylococcus aureus infections in pediatric or adult populations. Data synthesis: In the case of methicillin-resistant Staphylococcus aureus (MRSA) infections, three different randomized studies in pediatric patients showed effectiveness of ceftaroline. When used in the case of adult populations with MRSA bacteremia, a small trial of 16 patients showed 50% clinical success in patients with acute bacterial skin and skin structure infections versus 63% clinical success in patients with community-acquired bacterial pneumonia, respectively. Another case series of 6 refractory case reports showed 50% clinical success of ceftaroline in patients with MRSA bacteremia. Conclusions: Although there are few case reports and limited data to date, ceftaroline fosamil should continue to be studied as an alternative therapy in different type of infections.

Subject Areas

ceftaroline; cephalosporin; methicillin resistant Staphylococcus aureus MRSA; pediatrics; safety; community-acquired infection; bacteria infection; pneumonia; skin infection

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Rate this article
Views 0
Downloads 0
Comments 0
Metrics 0
Leave a public comment

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.