Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration

Version 1 : Received: 7 June 2018 / Approved: 8 June 2018 / Online: 8 June 2018 (12:28:07 CEST)

A peer-reviewed article of this Preprint also exists.

Puertas-Bartolomé, M.; Vázquez-Lasa, B.; San Román, J. Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration. Polymers 2018, 10, 768. Puertas-Bartolomé, M.; Vázquez-Lasa, B.; San Román, J. Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration. Polymers 2018, 10, 768.

Abstract

The effective treatment for chronic wounds constitute one of the most common worldwide health care problem due to the presence of high levels of proteases, free radicals and exudates in the wound, which constantly activate the inflammatory system avoiding the tissue regeneration. In this study, we describe a multifunctional bioactive and resorbable membrane with in-built antioxidant agent for the continuous quenching of free radicals as well as to control inflammatory response helping to promote the wound healing process. To reach that goal synthesized statistical copolymers of N-vinylcaprolactam (V) and 2-hydroxyethyl methacrylate (H) have been conjugated with catechol bearing hydrocaffeic acid (HCA) molecules. The natural polyphenol (catechol) is the key molecule responsible for the mechanism of adhesion of mussels, and provides the functionalized polymer conjugate a continuous antioxidant response, antiinflammatory effect, UV screen and bioadhesion in the moist environment of the human body, all of them key features in the wound healing process. Therefore, these novel mussel-inspired materials have an enormous potential of application and can act very positively, favoring and promoting the healing effect in chronic wounds.

Keywords

wound healing; catechol; conjugated; antioxidant; antiinflammatory; bioadhesion; UV shielding

Subject

Chemistry and Materials Science, Biomaterials

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.