Version 1
: Received: 1 June 2018 / Approved: 6 June 2018 / Online: 6 June 2018 (12:09:00 CEST)
How to cite:
Hyer, S.L.; Balani, J.; Shehata, H. Metformin in Pregnancy: Mechanisms and Clinical Applications. Preprints2018, 2018060091. https://doi.org/10.20944/preprints201806.0091.v1
Hyer, S.L.; Balani, J.; Shehata, H. Metformin in Pregnancy: Mechanisms and Clinical Applications. Preprints 2018, 2018060091. https://doi.org/10.20944/preprints201806.0091.v1
Hyer, S.L.; Balani, J.; Shehata, H. Metformin in Pregnancy: Mechanisms and Clinical Applications. Preprints2018, 2018060091. https://doi.org/10.20944/preprints201806.0091.v1
APA Style
Hyer, S.L., Balani, J., & Shehata, H. (2018). Metformin in Pregnancy: Mechanisms and Clinical Applications. Preprints. https://doi.org/10.20944/preprints201806.0091.v1
Chicago/Turabian Style
Hyer, S.L., Jyoti Balani and Hassan Shehata. 2018 "Metformin in Pregnancy: Mechanisms and Clinical Applications" Preprints. https://doi.org/10.20944/preprints201806.0091.v1
Abstract
Metformin use in pregnancy is increasing worldwide as randomised controlled trial (RCT) evidence is emerging demonstrating its safety and efficacy. The Metformin in Gestational Diabetes (MiG) RCT changed practice in many countries demonstrating that metformin had similar pregnancy outcomes to insulin therapy with less maternal weight gain and a high degree of patient acceptability. A multicentre RCT is currently assessing the addition of metformin to insulin in pregnant women with type 2 diabetes. RCT evidence is also available for the use of metformin for women with Polycystic Ovarian Syndrome and for non-diabetic women with obesity. No evidence of an increase in congenital malformations or miscarriages has been observed even when metformin is started before pregnancy and continued to term. Body composition and metabolic outcomes at two, seven and nine years have now been reported for the offspring of mothers treated in the MiG study. In this review, we will briefly discuss the action of metformin and then consider the evidence from the key clinical trials.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
