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@article{Han2004,
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@Article{Yeh2010,
   Author="Yeh, J. I.  and Pohl, E.  and Truan, D.  and He, W.  and Sheldrick, G. M.  and Du, S.  and Achim, C. ",
   Title="{{T}he crystal structure of non-modified and bipyridine-modified {P}{N}{A} duplexes}",
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@Article{Prlic2012,
   Author="Prlic, A.  and Yates, A.  and Bliven, S. E.  and Rose, P. W.  and Jacobsen, J.  and Troshin, P. V.  and Chapman, M.  and Gao, J.  and Koh, C. H.  and Foisy, S.  and Holland, R.  and Rimsa, G.  and Heuer, M. L.  and Brandstatter-Muller, H.  and Bourne, P. E.  and Willis, S. ",
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@Article{Dupradeau2008,
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   Title="{{R}.{E}.{D}{D}.{B}.: a database for {R}{E}{S}{P} and {E}{S}{P} atomic charges, and force field libraries}",
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% 27669644 
@Article{Svobodova2017,
   Author="Svobodova, M.  and Skouridou, V.  and Botero, M. L.  and Jauset-Rubio, M.  and Schubert, T.  and Bashammakh, A. S.  and El-Shahawi, M. S.  and Alyoubi, A. O.  and O'Sullivan, C. K. ",
   Title="{{T}he characterization and validation of 17$\beta$-estradiol binding aptamers}",
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   Year="2017",
   Volume="167",
   Pages="14--22",
   Month="Mar"
}

@Article{Adeel2017,
  author   = {Muhammad Adeel and Xiaoming Song and Yuanyuan Wang and Dennis Francis and Yuesuo Yang},
  title    = {Environmental impact of estrogens on human, animal and plant life: A critical review},
  journal  = {Environ. Int.},
  year     = {2017},
  volume   = {99},
  pages    = {107 - 119},
  issn     = {0160-4120},
  abstract = {AbstractBackground Since the inception of global industrialization, steroidal estrogens have become an emerging and serious concern. Worldwide, steroid estrogens including estrone, estradiol and estriol, pose serious threats to soil, plants, water resources and humans. Indeed, estrogens have gained notable attention in recent years, due to their rapidly increasing concentrations in soil and water all over the world. Concern has been expressed regarding the entry of estrogens into the human food chain which in turn relates to how plants take up and metabolism estrogens. Objectives In this review we explore the environmental fate of estrogens highlighting their release through effluent sources, their uptake, partitioning and physiological effects in the ecological system. We draw attention to the potential risk of intensive modern agriculture and waste disposal systems on estrogen release and their effects on human health. We also highlight their uptake and metabolism in plants. Methods We use \{MEDLINE\} and other search data bases for estrogens in the environment from 2005 to the present, with the majority of our sources spanning the past five years. Published acceptable daily intake of estrogens (μg/L) and predicted no effect concentrations (μg/L) are listed from published sources and used as thresholds to discuss reported levels of estrogens in the aquatic and terrestrial environments. Global levels of estrogens from river sources and from Waste Water Treatment Facilities have been mapped, together with transport pathways of estrogens in plants. Results Estrogens at polluting levels have been detected at sites close to waste water treatment facilities and in groundwater at various sites globally. Estrogens at pollutant levels have been linked with breast cancer in women and prostate cancer in men. Estrogens also perturb fish physiology and can affect reproductive development in both domestic and wild animals. Treatment of plants with steroid estrogen hormones or their precursors can affect root and shoot development, flowering and germination. However, estrogens can ameliorate the effects of other environmental stresses on the plant. Conclusions There is published evidence to establish a causal relationship between estrogens in the environment and breast cancer. However, there are serious gaps in our knowledge about estrogen levels in the environment and a call is required for a world wide effort to provide more data on many more samples sites. Of the data available, the synthetic estrogen, ethinyl estradiol, is more persistent in the environment than natural estrogens and may be a greater cause for environmental concern. Finally, we believe that there is an urgent requirement for inter-disciplinary studies of estrogens in order to better understand their ecological and environmental impact. },
  doi      = {https://doi.org/10.1016/j.envint.2016.12.010},
  keywords = {Estrogens, Environmental fate, Endocrine disrupting chemical (EDC), Plant uptake, Bioavailability, Aquatic ecology, Water and soil },
  url      = {http://www.sciencedirect.com/science/article/pii/S0160412016304494},
}

@Article{Pessoa2014,
  author   = {Germana P. Pessoa and Neyliane C. de Souza and Carla B. Vidal and Joana A.C. Alves and Paulo Igor M. Firmino and Ronaldo F. Nascimento and André B. dos Santos},
  title    = {Occurrence and removal of estrogens in {B}razilian wastewater treatment plants},
  journal  = {Sci. Total Environ.},
  year     = {2014},
  volume   = {490},
  pages    = {288 - 295},
  issn     = {0048-9697},
  abstract = {This paper evaluated the occurrence and removal efficiency of four estrogenic hormones in five biological wastewater treatment plants (WWTPs), located in the State of Ceará, Brazil. The five WWTPs comprised: two systems consisted of one facultative pond followed by two maturation ponds, one facultative pond, one activated sludge (AS) system followed by a chlorination step, and one upflow anaerobic sludge blanket (UASB) reactor followed by a chlorination step. Estrogen occurrence showed a wide variation among the analyzed influent and effluent samples. Estrone (E1) showed the highest occurrence in the influent (76%), whereas both 17β-estradiol (E2) and 17α-ethynylestradiol (EE2) presented a 52% occurrence, and the compound 17β-estradiol 17-acetate (E2-17A), a 32% one. The occurrence in the effluent samples was 48% for E1, 28% for E2, 12% for E2-17A, and 40% for EE2. The highest concentrations of E1 and EE2 hormones in the influent were 3050 and 3180ngL−1, respectively, whereas E2 and E2-17A had maximum concentrations of 776 and 2300ngL−1, respectively. The lowest efficiencies for the removal of estrogenic hormones were found in WWTP consisted of waste stabilization ponds, ranging from 54 to 79.9%. The high-rate systems (AS and UASB), which have chlorination as post-treatment, presented removal efficiencies of approximately 95%.},
  doi      = {http://dx.doi.org/10.1016/j.scitotenv.2014.05.008},
  keywords = {Endocrine disrupting chemical, Hormone, Occurrence, Removal, Wastewater treatment plant},
  url      = {http://www.sciencedirect.com/science/article/pii/S0048969714006664},
}

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