Preprint Review Version 1 This version is not peer-reviewed

Annexins in Translational Research: HIDDEN Treasures to Be Found

Version 1 : Received: 25 May 2018 / Approved: 27 May 2018 / Online: 27 May 2018 (11:32:34 CEST)

A peer-reviewed article of this Preprint also exists.

Schloer, S.; Pajonczyk, D.; Rescher, U. Annexins in Translational Research: Hidden Treasures to Be Found. Int. J. Mol. Sci. 2018, 19, 1781. Schloer, S.; Pajonczyk, D.; Rescher, U. Annexins in Translational Research: Hidden Treasures to Be Found. Int. J. Mol. Sci. 2018, 19, 1781.

Journal reference: Int. J. Mol. Sci. 2018, 19, 1781
DOI: 10.3390/ijms19061781

Abstract

The vertebrate annexin superfamily (AnxA) consists of 12 members of a calcium (Ca2+) and phospholipid binding protein family which share a high structural homology. In keeping with this hallmark feature, annexins have been implicated in the Ca2+-controlled regulation of a broad range of membrane events. In this review, we identify and discuss several themes of annexin actions that hold a potential therapeutic value, namely the regulation of the immune response and the control of tissue homeostasis, and that repeatedly surface in the annexin activity profile. Our aim is to identify and discuss those annexin properties which might be exploited from a translational science and specifically clinical point of view.

Subject Areas

annexins; inflammation; wound healing; host-pathogen interplay; drug target; translational research

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