Preprint Article Version 1 This version is not peer-reviewed

Synthesis and Antibacterial Activity of Acylhydrazone Derivatives from Dehydroabietic Acid

Version 1 : Received: 30 April 2018 / Approved: 2 May 2018 / Online: 2 May 2018 (12:19:30 CEST)

How to cite: Zhou, Z.; Zhou, T. Synthesis and Antibacterial Activity of Acylhydrazone Derivatives from Dehydroabietic Acid. Preprints 2018, 2018050033 (doi: 10.20944/preprints201805.0033.v1). Zhou, Z.; Zhou, T. Synthesis and Antibacterial Activity of Acylhydrazone Derivatives from Dehydroabietic Acid. Preprints 2018, 2018050033 (doi: 10.20944/preprints201805.0033.v1).

Abstract

Senven new acylhydrazone derivatives of dehydroabietic acid were synthesized from dehydroabietic acid through benzylic oxidation, condensation with hydrazine hydrate, followed by nucleophilic substitution reactions with a variety of substituted aromatic acids. The structures of the synthesized compounds were characterized by IR、1H NMR、MS. The antibacterial activities of the synthesized compounds were evaluated by disk diffusion method. Antibacterial activities studies showed that acylhydrazone derivatives of dehydroabietic acid exhibited inhibitory activities against E. coli, S. aureus and B. subtilis. Among the senven compounds, dehydroabietic acid p-fluorobenzoyl hydrazone showed the strongest inhibitory activity against B. subtilis and S. aureus, the diameters of antibacterial rings reached 1.68 and 1.45 cm, respectively.

Subject Areas

dehydroabietic acid; acylhydrazone; sythesis; antibacterial activity

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