1) Objective: to assess staff time and hospital medication costs between One-Stop Dispensing (OSD) and the Traditional Medication System (TMS), and to evaluate patient perspectives on OSD. 2) Methods: The study was conducted at Hvidovre Hospital, University of Copenhagen, Denmark in an elective gastric surgery and acute orthopedic surgery department. The study was designed as an intervention study with a historical control group receiving TMS. The intervention group included adult patients able to self-administer medication. Time measurements included time used by nurses and pharmacy staff to dispense and administer medication as well as medication dialogue. Medication costs with two days of discharge medication were compared between OSD and TMS. Patient satisfaction related to OSD was evaluated by a questionnaire based on a five-point Likert scale ('very poor' (1) to 'very good' (5)). 3) Results: Seventy-eight elective and 70 acute patients were included. Compared with TMS, OSD significantly reduced used staff time by an average of 12 minutes (P < 0.0001) per patient per hospitalization. Overall, there was no significant increase in medication cost per patient for OSD (1.68 € [CI 95 -0.51―3.87]) (P = 0.13). Mean scores for the OSD satisfaction questionnaire ranged from 4.3―4.8. OSD was associated with significantly lower used staff time. 4) Conclusion: Staff time in OSD was significantly lower, there were no differences in medication costs and the patients were overall satisfied with OSD.
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