Preprint Review Version 1 This version is not peer-reviewed

Anti-Inflammatory Agents from Marine Sponges: An Update

Version 1 : Received: 9 April 2018 / Approved: 10 April 2018 / Online: 10 April 2018 (07:52:19 CEST)

How to cite: Ruocco, N.; Albarano, L.; Capone, F.; Costantini, S.; Costantini, M. Anti-Inflammatory Agents from Marine Sponges: An Update. Preprints 2018, 2018040113 (doi: 10.20944/preprints201804.0113.v1). Ruocco, N.; Albarano, L.; Capone, F.; Costantini, S.; Costantini, M. Anti-Inflammatory Agents from Marine Sponges: An Update. Preprints 2018, 2018040113 (doi: 10.20944/preprints201804.0113.v1).

Abstract

Inflammation is a dynamic process, in which pro-inflammatory cytokines, such as tumor necrosis factor, interleukins and vascular endothelial growth factor have central roles. A number of drugs or active agents have been developed to treat inflammation, able to reduce the activity of specific cytokines or their receptors to block lymphocyte trafficking into tissues, to prevent the binding of monocyte-lymphocyte co-stimulatory molecules, or to deplete B lymphocytes. Furthermore, inflammation is a critical component of tumor progression, fostering new anti-inflammatory therapeutic approaches against cancer development. In the few last decades marine environment have been recognized to be a rich sources of bioactive metabolites with varied biological and pharmacological activities, including anti-inflammatory effects. A lot of marine phyla were considered for their significance respect to pharmacological active compounds, including bacteria, fungi, algae, soft corals, nudibranchs, bryozoans, tunicates and especially sponges. In particular, marine sponges have been considered as a gold mine because they contain different secondary metabolites and provide novel natural products with a remarkable chemical diversity. Considering that the last review on anti-inflammatory agents from marine sponges dates back to 2005, and after this many studies report results on the identification of natural compounds from sponges with this activity, here we report an update on anti-inflammatory agents, focusing our attention on marine sponges as promising their sources.

Subject Areas

anti-inflammatory agents; cancer; sponges

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