Preprint
Article

MS/MS-Guided Isolation of Clarinoside, a New Anti-Inflammatory Pentalogin Derivative

Submitted:

24 March 2018

Posted:

26 March 2018

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Abstract
Re-investigation of the chemical composition of the annual plant Mitracarpus scaber Zucc. led to the identification of a new pentalogin derivative containing a rare quinovose moiety. While the planar structure has been fully determined using tandem MS and quantum mechanics calculations (QM), the tridimensional structure was unraveled after isolation and NMR analysis. The absolute configuration was assigned by comparison of experimental and theoretical SRCD spectra. Both compounds were tested for anti-inflammatory activity and compound 1 showed the ability to inhibit the production of interleukin-8 (Il-8) with an IC50 of 9.17 µM.
Keywords: 
Mitracarpus scaber Zucc.; pentalogin; anti-inflammatory; MS/MS; Il-8
Subject: 
Chemistry and Materials Science  -   Analytical Chemistry
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.

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