Preprint Review Version 1 This version is not peer-reviewed

Induced Pluripotent Stem Cells Technology and Cardiomyocyte Generation: Progress, Uncertainties and Challenges in the Biological Features and Clinical Applications

Version 1 : Received: 14 March 2018 / Approved: 15 March 2018 / Online: 15 March 2018 (05:02:41 CET)

How to cite: Di Baldassarre, A.; Cimetta, E.; Bollini, S.; Gaggi, G.; Ghinassi, B. Induced Pluripotent Stem Cells Technology and Cardiomyocyte Generation: Progress, Uncertainties and Challenges in the Biological Features and Clinical Applications. Preprints 2018, 2018030115 (doi: 10.20944/preprints201803.0115.v1). Di Baldassarre, A.; Cimetta, E.; Bollini, S.; Gaggi, G.; Ghinassi, B. Induced Pluripotent Stem Cells Technology and Cardiomyocyte Generation: Progress, Uncertainties and Challenges in the Biological Features and Clinical Applications. Preprints 2018, 2018030115 (doi: 10.20944/preprints201803.0115.v1).

Abstract

Human induced pluripotent stem cells (hiPSCs) are reprogrammed cells that have hallmarks similar to embryonic stem cells including the capacity of self-renewal and differentiation into cardiac myocytes. The improvements in reprogramming and differentiating methods achieved in the past 10 years widened the use of hiPSCs, especially in cardiac research. hiPSC-derived cardiac myocytes (CMs) recapitulate phenotypic differences caused by genetic variations, making them human attractive disease models and useful tools for drug discovery and toxicology testing. In addition, hiPSCs can be used as source cells for cardiac regeneration in animal models. Here, we review the advances in the genetic and epigenetic control of cardiomyogenesis that underlies the significant improvement of the induced reprogramming of somatic cells to CMs. We also cover the phenotypic characteristics of the hiPSCs derived CMs, their ability to rescue injured CMs through paracrine effects, the novel approaches in tissue engineering for hiPSC-derived cardiac tissue generation, and finally, their potential use in biomedical applications.

Subject Areas

regenerative medicine; reprogramming; cardiac differentiation; secretoma; tissue engineering

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Rate this article
Views 0
Downloads 0
Comments 0
Metrics 0
Leave a public comment

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.